{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:23:56Z","timestamp":1790796236938,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry"],"published-print":{"date-parts":[[2002,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>CD2 is expressed by T and natural killer (NK) cells and has been reported in T\/NK cell lineage neoplasms as well as in immature B\u2010lymphoblastic and myeloid leukemias. Although CD2+ B\u2010cells have been identified in normal fetal and postnatal thymus, they have not been reported in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed flow cytometric immunophenotypic data on consecutive low\u2010grade B\u2010cell leukemias and lymphomas to investigate the frequency of CD2 expression. We also reviewed samples from normal healthy donors to determine whether there is a normal CD2+ B\u2010cell population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CD2 expression (partial or complete) was observed in 13 of 83 (16%) chronic lymphocytic leukemias (CLL), 16 of 29 (55%) follicle center lymphomas (FCL), 3 of 12 (25%) hairy cell leukemias (HCL), 0 of 6 mantle cell lymphomas (MCL), 8 of 28 (29%) large cell lymphomas (LCL), and in 0 of 5 marginal zone\/mucosa\u2010associated lymphoid tissue lymphomas (MZL\/MALT). We determined that 5.74 \u00b1 2.46% (mean \u00b1 SD) of normal peripheral blood B cells and 6.48 \u00b1 1.62 % (mean \u00b1 SD) of normal bone marrow B cells coexpress CD2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CD2 expression in B\u2010cell neoplasia is a more prevalent phenomenon than previously appreciated. Normal CD2+ B\u2010cell populations are observed in adults and may represent the nonmalignant counterpart of CD2+ B\u2010cell neoplasms. Cytometry (Clin. Cytometry) 50:243\u2013248, 2002. Published 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.10131","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T05:17:22Z","timestamp":1034140642000},"page":"243-248","source":"Crossref","is-referenced-by-count":35,"title":["CD2 is expressed by a subpopulation of normal B cells and is frequently present in mature B\u2010cell neoplasms"],"prefix":"10.1002","volume":"50","author":[{"given":"Douglas W.","family":"Kingma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Imus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu 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