{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T05:04:55Z","timestamp":1724562295411},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T00:00:00Z","timestamp":1112140800000},"content-version":"vor","delay-in-days":8915,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry"],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BioPEPR is a cathode ray tube scanning device that has been developed for the prescreening of cervical smears. Cervical samples are collected in suspension, syringed, counted and spread across a microscope slide. Feulgen\u2010Thionine with Congo Red is used as the staining procedure. Fields of 6 \u00d7 8 mm are scanned at 1 \u03bc resolution, using an intermediate photographic step. Morphologic parameters of the cells are measured, as called for by a hierarchical decision strategy. Analysis speed is currently about 4 min per smear; improvements of at least a factor of four are expected. A field test of BioPEPR is being undertaken in cooperation with a local population screening program. In the study two smears are made from each woman; the first is prepared according to the Papanicolaou technique while the second is prepared and stained according to the BioPEPR methods. In addition to smears from the population screening program a number of possibly abnormal smears are obtained from several gynecological clinics. To date approximately 3500 \u201csecond\u201d smears have been analyzed by the BioPEPR system. The results show a missed positive rate on the order of a few percent (no missed positives were more severe than a slight dysplasia), and a false alarm rate of about 24%. A further analysis of the age distribution of the false alarm rate shows that a large proportion came from women above the age of 50; the false alarm rate is about 20% for women under the age of 50.<\/jats:p>","DOI":"10.1002\/cyto.990010305","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T15:28:14Z","timestamp":1123514894000},"page":"200-203","source":"Crossref","is-referenced-by-count":15,"title":["Field test results using the BioPEPR cervical smear prescreening system"],"prefix":"10.1002","volume":"1","author":[{"given":"D. J.","family":"Zahniser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Oud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. T.","family":"Raaijmakers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P.","family":"Vooys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Van de Walle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"117","article-title":"Optimizing cervical cell classifiers","volume":"2","author":"Castleman KR","year":"1980","journal-title":"Anal Quant Cytol"},{"key":"e_1_2_1_3_2","first-page":"122","article-title":"Field test and experimental use of CYBEST Model 2 for practical gynecologic mass screening","volume":"1","author":"Tanaka N","year":"1979","journal-title":"Anal Quant Cytol"},{"key":"e_1_2_1_4_2","first-page":"15","volume-title":"The Automation of Cancer Cytology and Cell Image Analysis","author":"Wied GL","year":"1976"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","unstructured":"ZahniserDJ:The development of a fully automatic system for the prescreening of cervical smears: BioPEPR. PhD Thesis University of Nijmegen Nijmegen The Netherlands 1979","DOI":"10.1177\/27.1.86581"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/27.1.86581"}],"container-title":["Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.990010305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.990010305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T16:16:14Z","timestamp":1699805774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.990010305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["10.1002\/cyto.990010305"],"URL":"https:\/\/doi.org\/10.1002\/cyto.990010305","archive":["Portico"],"relation":{},"ISSN":["0196-4763","1097-0320"],"issn-type":[{"value":"0196-4763","type":"print"},{"value":"1097-0320","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}