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Group I comprised normal gastric mucosal cells; group II, chronic atrophic gastric mucosal cells originating from a carcinoma free stomach; group III, chronic atrophic gastric mucosal cells originating from a carcinoma bearing stomach; and group IV, malignant gastric mucosal cells. The heparin concentrations used were 1.25, 1.5, and 5 U\/ml cell suspension. Heparin caused increases in fluorescence intensity and in coefficients of variation, which are interpreted as a reflection of alterations in chromatin structure. For the four groups investigated, the heparin\u2010initiated changes were dependent, in varying degree, on concentration and time. Group I showed a much more extensive sensitivity to heparin than group IV. Group II and III reacted similarly to group I or group IV, depending on the source, i.e., either a carcinoma\u2010free stomach or a carcinoma\u2010bearing stomach. Further extension of this method might yield information concerning the real premalignant potential of a specific case of chronic atrophic gastritis.<\/jats:p>","DOI":"10.1002\/cyto.990040313","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T16:32:49Z","timestamp":1123518769000},"page":"268-275","source":"Crossref","is-referenced-by-count":4,"title":["Difference in chromatin sensitivity to heparin of chronic atrophic gastritis, of carcinoma\u2010free and carcinoma\u2010bearing stomach in comparison with normal gastric mucosa and gastric carcinoma as revealed by flow 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