{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T11:13:59Z","timestamp":1697886839237},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":6825,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Morphometric analysis of nuclear sizes and shapes was carried out on semithin sections of lymph node for 21 patients suffering from non\u2010Hodgkin's peripheral T\u2010cell malignant lymphoma (ML) (excluding mycosis and S\u00e9zary syndrome). Twenty cases of B\u2010cell ML and three cases of S\u00e9zary syndrome with massive lymph node infiltration were also studied as references. Wright and Isaacson's recent proposals were applied to classify the peripheral T\u2010cell MLs into monomorphic medium\u2010cell ML (eight cases), pleomorphic ML (nine cases), and monomorphic large\u2010cell ML (four cases). These three classes were readily distinguishable by morphometric analysis of nuclear sizes. Nuclear areas and their coefficients of variation were higher in pleomorphic MLs than in monomorphic medium\u2010cell MLs (p &lt; 0.01). Large\u2010cell monomorphic MLs were set apart by the histograms of their nuclear sizes. The mitoses were evaluated on histological sections and found to be more numerous in pleomorphic ML than in monomorphic medium\u2010cell ML (p &lt; 0.05). Nuclear irregularity in the 21 cases of peripheral T\u2010cell ML was lower than in S\u00e9zary cells. Morphometry clearly demonstrates the morphological distinctiveness of the subclasses of peripheral T\u2010cell ML. Their biological significance has yet to be determined.<\/jats:p>","DOI":"10.1002\/cyto.990070412","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T13:56:40Z","timestamp":1123509400000},"page":"371-377","source":"Crossref","is-referenced-by-count":6,"title":["Can peripheral T\u2010Cell lymphomas be morphologically subclassified? A morphometric approach to 21 cases"],"prefix":"10.1002","volume":"7","author":[{"given":"Fran\u00e7ois","family":"Sigaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Flandrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Valensi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gaulard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Castaigne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Therese","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Luc","family":"Harousseau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/79.3.285"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/ajcp\/80.3.391","article-title":"T8 chronic lymphocytic leukemia, a destructive disorder related to T8 lymphocytosis","volume":"80","author":"Brisbane J","year":"1983","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb02901.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.9.954"},{"key":"e_1_2_1_6_2","first-page":"190","article-title":"Morphometry of normal human lymphoid tissues. 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