{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T15:26:16Z","timestamp":1743348376849},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":6641,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study the possibility of classifying carcinoma in situ and normal specimens by measuring normal\u2010appearing intermediate cells was explored. Twenty\u2010five histologically verified carcinoma in situ specimens and 99 normal specimens, matched with the abnormal specimens for age and use or nonuse of an oral hormonal contraceptive, were examined. The smears were monolayer preparations stained with Thionin\u2010Feulgen Congored. Twenty\u2010one nuclear features were measured. A discrimination among the experimental groups could be made on the basis of the relationship between two features, area and average optical density (AOD). A regression of AOD on area for each smear was performed. The correlation, coefficient of variation, slope, intercept, as well as the mean of the AOD level and the age of the subject were used in a discriminant analysis. This resulted in a smear classification with a false\u2010positive rate of 14% and a missed\u2010positive rate of 32%. When contraceptive use was taken into account the overall classification was improved with a false\u2010positive rate of 12% and a missed\u2010positive rate of 20%.<\/jats:p>","DOI":"10.1002\/cyto.990080102","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T14:49:56Z","timestamp":1123512596000},"page":"9-13","source":"Crossref","is-referenced-by-count":7,"title":["Carcinoma in situ specimen classification based on intermediate cell measurements"],"prefix":"10.1002","volume":"8","author":[{"given":"Michael W.","family":"Katzko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin M. M.","family":"Pahlplatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Oud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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Automated cytologic screening system for uterine cancer, utilizing image analysis processing","volume":"4","author":"Tanaka N","year":"1982","journal-title":"Anal Quant Cytol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990060105"},{"key":"e_1_2_1_16_2","unstructured":"de ValkJPJ OudPS VincentJ: Detectability and diagnostic output for quality assessment of classification of differently stained cervical cells.IEEE Conference Record on the 2nd International Conference on Visual Psychophysics and Medical Imaging Brussels 75\u201380 1981."},{"key":"e_1_2_1_17_2","first-page":"257","article-title":"Cytomorphometric markers for uterine cancer in intermediate cells","volume":"2","author":"Wied GL","year":"1980","journal-title":"Anal Quant Cytol"},{"key":"e_1_2_1_18_2","first-page":"243","article-title":"Intermediate cell markers for malignancy: Consistency of expression","volume":"6","author":"Wied GL","year":"1984","journal-title":"Anal Quant Cytol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/27.1.86581"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990010305"}],"container-title":["Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.990080102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.990080102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T07:32:24Z","timestamp":1697873544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.990080102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/cyto.990080102"],"URL":"https:\/\/doi.org\/10.1002\/cyto.990080102","archive":["Portico"],"relation":{},"ISSN":["0196-4763","1097-0320"],"issn-type":[{"value":"0196-4763","type":"print"},{"value":"1097-0320","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}