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Human ovarian cancer xenografts in nude mice from a primary and recurrent tumor of the same patient were studied. The response to intraperitoneal application of cis\u2010platinum was assessed by tumor volume measurements, changes in labeling indices by autoradiography, and dual parameter flow cytometry. Sequential tissue samples were taken from each tumor using fine needle aspirations as a microbiopy method. Pretherapy samples were compared to multiple specimens collected up to 18 days after therapy. Morphologic changes of each specimen were also assessed. Cis\u2010platinum affects malignant cells in the G<jats:sub>1B<\/jats:sub>, S, G<jats:sub>2A<\/jats:sub>, and G<jats:sub>2B<\/jats:sub> compartments with various intensities and different time frames, depending on the drug sensitivity of each individual tumor.<\/jats:p>","DOI":"10.1002\/cyto.990080208","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T14:18:12Z","timestamp":1123510692000},"page":"153-162","source":"Crossref","is-referenced-by-count":5,"title":["In vivo cell kinetic effects of cis\u2010platinum on human ovarian cancer xenografts measured by dual parameter flow cytometry"],"prefix":"10.1002","volume":"8","author":[{"given":"Bernd\u2010uwe","family":"Sevin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Pollack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hervy E.","family":"Averette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Donato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66011-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(70)90195-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/S0002-9378(16)33395-6","article-title":"Cell kinetics and programmed chemotherapy for gynecologic cancer. 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