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A significant hyperdiploid cell population with a mean DNA index of 1.23 (range 1.17\u20131.31) was found in six gonads. Hyperdiploid aneuploidy was found in gonads without, as well as with, complete spermatogenesis. In none of the six cases did the surgical biopsy show evidence of early testicular neoplasia by morphology or by immunohistochemical methods with antibodies against carcinoma in situ. This indicates that aneuploidies in maldescended testes do not necessarily indicate malignancy. It may be speculated that hyperdiploid aneuploidy is related to the development of preneoplastic lesions.<\/jats:p>","DOI":"10.1002\/cyto.990120111","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T13:57:24Z","timestamp":1123509444000},"page":"77-81","source":"Crossref","is-referenced-by-count":6,"title":["DNA distributions in maldescended testes: Hyperdiploid aneuploidy without evidence of germ cell neoplasia"],"prefix":"10.1002","volume":"12","author":[{"given":"O. P. 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