{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T09:41:14Z","timestamp":1698313274655},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":3646,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry"],"published-print":{"date-parts":[[1995,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic CD4+ T\u2010lymphocytopenia (ICL) in HIV\u2010seronegative patients is a newly described, rare entity. The common underlying abnormality is a usually stable depletion in CD4+ lymphocytes in patients, some of which have unexplained opportunistic infections. We present a previously unreported condition of an asymptomatic individual with CD4+ T\u2010lymphocytopenia and a selective lgA deficiency. The subject is a 35\u2010year\u2010old healthy white male with a documented 5\u2010year history of low CD4+ T cell counts. He has been repeatedly HIV seronegative and has no risk factors for HIV infection. Data were obtained from several laboratories over a 5\u2010year period and include standard WBC differentials, HIV testing, serum immunoglobulin quantitation, mitogen stimulation assays, diphtheria and tetanus antitoxin titers, and flow cytometric immunophenotyping. The composite results show a subject with a normal white blood cell count, an absolute lymphopenia, a slight granulocytosis, and a selective lgA deficiency. Leukocyte subset analyses show essentially normal B but significantly altered T cell phenotypes. The normal CD4:CD8 ratio shows extreme inversion, primarily due to CD4 T\u2010lymphocytopenia. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cyto.990220108","type":"journal-article","created":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T21:52:13Z","timestamp":1120168333000},"page":"40-44","source":"Crossref","is-referenced-by-count":1,"title":["Idiopathic CD4 + T\u2010lymphocytopenia: Analysis of a patient with selective IgA deficiency and no evidence of HIV infection"],"prefix":"10.1002","volume":"22","author":[{"given":"Dianne","family":"Vertes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"81s","article-title":"Monoclonal antibody analysis of T cell subsets in 40 patients with immunodeficiencies","volume":"2","author":"Aiuti F","year":"1982","journal-title":"J Clin Immunol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280614"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34394196614.x"},{"key":"e_1_2_1_5_2","first-page":"1","article-title":"Guidelines for the performance of CD4+ T\u2010Cell determinations in persons with human immunodeficiency virus infection","volume":"41","author":"CDC","year":"1992","journal-title":"MMWR"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198108273050905"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280604"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199308000-00024"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280610"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/archderm.1993.01680280064012","article-title":"Idiopathic CD4+ lymphocyte deficiency","volume":"129","author":"Goodrich AL","year":"1993","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_11_2","first-page":"32S","article-title":"Light scatter as an adjunct to cellular immuno\u2010fluorescence in flow cytometric systems","volume":"2","author":"Hansen W","year":"1982","journal-title":"J Clin Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280602"},{"key":"e_1_2_1_13_2","unstructured":"LandeyA AuerR DuqueR et al: Clinical applications of flow cytometry: Quality assurance and immunophenotyping of peripheral blood lymphocytes. 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