{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:39:57Z","timestamp":1761154797765},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":3462,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry"],"published-print":{"date-parts":[[1995,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have suggested that \u03b3\u03b4 T cells can be increased in HIV\u2010l;1\u2010seropositive individuals, although characterization of \u03b3\u03b4 T cell subtypes and correlation with clinical status of these patients have not been performed. We investigated groups of adult HIV\u2010seropositive persons to determine the prevalence of elevated levels of \u03b3\u03b4 T cells and whether any \u03b3\u03b4 T cell subtypes were preferentially expressed. Since a large proportion of human \u03b3\u03b4 T cells appear to be reactive to proteins encoded by mycobacteria, we also examined our patients for the incidence of mycobacterial infection. Our results show that a significant number of HIV\u2010positive patients have an elevated number of \u03b3\u03b4 T cells in their peripheral blood as compared to normal controls. HIV\u2010seropositive patients with clinical or laboratory evidence of mycobacterial infection had statistically significant increases in the percentage and total numbers of \u03b3\u03b4 T cells over the HIV\u2010positive persons without mycobacterial infection. An examination of the subtypes of \u03b3\u03b4 T cells revealed that certain subtypes such as V\u03b3\u03b49<jats:sup>+<\/jats:sup> and V\u03b42<jats:sup>+<\/jats:sup> T cells were preferentially elevated in the mycobacteria\u2010positive patients. These results suggest that an increased number of \u03b3\u03b4 T cells in HIV\u2010positive patients is most often seen in the setting of an opportunistic mycobacterial infection and that specific \u03b3\u03b4 T cell subtypes are stimulated under these conditions. The role of these increased numbers of \u03b3\u03b4 T cells in HIV\u2010associated disease is unclear but is likely a component of the response and degree of host resistance to this organism. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cyto.990220308","type":"journal-article","created":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T21:47:56Z","timestamp":1120168076000},"page":"211-216","source":"Crossref","is-referenced-by-count":7,"title":["Peripheral \u03b3\u03b4 T\u2010cell population in HIV\u2010infected individuals with mycobacterial 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