{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:01:55Z","timestamp":1791345715029,"version":"4.3.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Pt A"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD160 is a GPI\u2010anchored Ig\u2010like receptor identified by the BY55 mAb on human circulating CD56<jats:sup>dim+<\/jats:sup> NK cells and TCR\u03b3\u03b4 lymphocytes. In addition, while most intestinal T lymphocytes express it, only a minor circulating CD4<jats:sup>+<\/jats:sup> or CD8<jats:sup>+<\/jats:sup> T lymphocyte subset is CD160<jats:sup>+<\/jats:sup>. Here we describe a population of CD4<jats:sup>+<\/jats:sup>CD160<jats:sup>+<\/jats:sup> human blood T lymphocytes of circulating cutaneous T cells. These rare T lymphocytes represent 2.1 \u00b1 1.9% of the circulating CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> T cells, coexpress CD8\u03b1\u03b1, CD244, and perforin but lack CD28 expression, a phenotype corresponding to effector memory cytotoxic T\u2010lymphocytes. Functional studies further confirmed their cytotoxic potential. These cells lack \u03b1E\u03b27 integrin and CCR7 expression but do express skin\u2010addressing molecules CLA, and CCR4. In normal human skin, CD4<jats:sup>+<\/jats:sup>CD160<jats:sup>+<\/jats:sup> cells represent 34.6 \u00b1 14.7% of the CD4<jats:sup>+<\/jats:sup> T lymphocytes extracted by collagenase treatment. These T cells coexpress CLA (81 \u00b1 13.6%), CCR4 (62.3 \u00b1 15.9%), and some CD8\u03b1\u03b1 (19.6 \u00b1 13%) or CCR7 (24.4 \u00b1 11.7%) expression. Cutaneous T\u2010cell lymphoma cells express the natural killer receptor KIR3DL2 (CD158k) used as a tumor marker. Not only we confirmed the expression of this marker in the blood and\/or skin of mycosis fungoides patients but we also show for the first time CD158k expression (often associated with CD160) on cutaneous CD4<jats:sup>+<\/jats:sup> T cells from healthy individuals (25.3 \u00b1 15%). Therefore, CD4<jats:sup>+<\/jats:sup>CD160<jats:sup>+<\/jats:sup> T cells expressing CD158k might represent specialized cutaneous lymphocytes devoted to immune surveillance, from which could originate cutaneous T\u2010cell lymphomas such as mycosis fungoides. \u00a9 2014 International Society for Advancement of Cytometry<\/jats:p>","DOI":"10.1002\/cyto.a.22512","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T16:23:07Z","timestamp":1405700587000},"page":"869-882","source":"Crossref","is-referenced-by-count":21,"title":["Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4<sup>+<\/sup> T\u2010lymphocyte subset in normal and mycosis fungoides skin"],"prefix":"10.1002","volume":"85","author":[{"given":"Nouhoum","family":"Sako","sequence":"first","affiliation":[{"name":"INSERM U976, F\u201075010 Paris France"},{"name":"Univ Paris Diderot, Sorbonne Paris Cit\u00e9 UMR\u2010S 976, F\u201075739 Paris 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