{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:42:28Z","timestamp":1783464148622,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T00:00:00Z","timestamp":1552089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytometry Pt A"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ischemic lesions of the heart, including myocardial infarction, are the most common pathologies of human cardiovascular system. Despite all the research and achievements of medicine in this field, the mortality from this disease remains heavy. Therefore, studying of processes occurring in the myocardium in the early and late postinfarction periods remains important. Rat left ventricular cardiomyocyte (CMC) ploidy, hypertrophy, hyperplasia, and ultrastructure were investigated in 2, 6, and 26\u2009weeks after experimental myocardial infarction, caused by permanent ligation of left coronary artery. Cytofluorimetric study of CMC ploidy revealed no difference between normal, sham\u2010operated, and infarcted animals for all the tested stages. However, interference microscopy indicated significant changes in cells size. CMC dry mass of infarcted rats in 2 weeks after surgery was 1.5 times lower than in control and sham operated groups. Electron microscopy analysis of CMC revealed disruption of sarcomere structure. However, in 6 weeks after surgery CMC dry mass was 1.6 times higher than in control. In 26\u2009weeks after myocardial infarction CMC dry mass exceeded control only in peri\u2010infarction zone. Cell counting showed that the number of left ventricular CMC, reduced as a result of myocardial infarction, was not restored during myocardial remodeling. \u00a9 2019 International Society for Advancement of Cytometry<\/jats:p>","DOI":"10.1002\/cyto.a.23739","type":"journal-article","created":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T03:09:01Z","timestamp":1552187341000},"page":"730-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rat Left Ventricular Cardiomyocytes Characterization in the Process of Postinfarction Myocardial Remodeling"],"prefix":"10.1002","volume":"95","author":[{"given":"Ekaterina V.","family":"Baidyuk","sequence":"first","affiliation":[{"name":"Laboratory of Cell Pathology Institute of Cytology of the Russian Academy of Sciences  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina A.","family":"Sakuta","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Pathology Institute of Cytology of the Russian Academy of Sciences  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail L.","family":"Vorobev","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Pathology Institute of Cytology of the Russian Academy of Sciences  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Stepanov","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Pathology Institute of Cytology of the Russian Academy of Sciences  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei A.","family":"Karpov","sequence":"additional","affiliation":[{"name":"Laboratory of Nanotechnology Almazov National Medical Research Center  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Rogoza","sequence":"additional","affiliation":[{"name":"Pathoanatomic laboratory of medical rehabilitation complex Almazov National Medical Research Center  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris N.","family":"Kudryavtsev","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Pathology Institute of Cytology of the Russian Academy of Sciences  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2008.02.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.07.022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.1.76"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H2183"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214608110"},{"key":"e_1_2_6_7_1","first-page":"187","volume-title":"Growth of the Heart in Health and Disease","author":"Ferrans VJ","year":"1984"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0163"},{"key":"e_1_2_6_9_1","first-page":"217","article-title":"Characterisation of postnatal growth of the murine heart","volume":"204","author":"Leu M","year":"2001","journal-title":"Brain Struct Funct"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0668-z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595181"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63068"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.231498"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.118380"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.02.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2014.09.003"},{"issue":"11","key":"e_1_2_6_17_1","first-page":"1158","article-title":"The cellular mechanisms of the regeneration of the cirrhotic liver in rats. I. The correlation of the processes of cellular proliferation, polyploidization and hypertrophy after the cessation of chronic exposure to carbon tetrachloride","volume":"38","author":"Sakuta GA","year":"1996","journal-title":"Tsitologiia"},{"issue":"5","key":"e_1_2_6_18_1","first-page":"379","article-title":"Cellular mechanisms of cirrhotic rat liver regeneration. Ii. Proliferation, polyploidization and hypertrophy after partial hepatectomy","volume":"47","author":"Sakuta GA","year":"2005","journal-title":"Tsitologiia"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1990519X13020028"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02915139"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1990519X16020036"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1990519X15010022"},{"key":"e_1_2_6_23_1","first-page":"339","article-title":"Lack of proportionality between gene dosage and total muscle protein content in the rat heart","volume":"36","author":"Brodsky VY","year":"1992","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_24_1","first-page":"537","article-title":"Cardiomyocyte and hepatocyte dry weight in mammal species with different body weight","volume":"29","author":"Anatskaya OV","year":"1996","journal-title":"Acta Histochem Cytochem"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22811"},{"key":"e_1_2_6_26_1","first-page":"599","article-title":"Auramine O\u2010SO2 a highly fluorescent Schiff\u2010type reagent for DNA in the Feulgen reaction","volume":"9","author":"Kasten FH","year":"1961","journal-title":"J Histochem Cytochem"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890430"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1990519X17060086"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.132910"},{"key":"e_1_2_6_30_1","first-page":"70","volume-title":"Reproduction of Growth and Hyperplasia of Cardiac Muscle Cells","author":"Rumyantsev PP","year":"1991"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.035"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-017-0826-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11682"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024307"},{"key":"e_1_2_6_35_1","first-page":"343","volume-title":"An Introduction to Error Analysis. The Study of Uncertainties in Physical Measurements","author":"Taylor JR","year":"1997"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-011"},{"issue":"39","key":"e_1_2_6_37_1","first-page":"1654","article-title":"Pathophysiology of ischemic myocardial dysfunction","volume":"126","author":"Heusch G","year":"1996","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht018"}],"container-title":["Cytometry Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.a.23739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.a.23739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cyto.a.23739","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.a.23739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T10:16:03Z","timestamp":1694168163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.a.23739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,9]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/cyto.a.23739"],"URL":"https:\/\/doi.org\/10.1002\/cyto.a.23739","archive":["Portico"],"relation":{},"ISSN":["1552-4922","1552-4930"],"issn-type":[{"value":"1552-4922","type":"print"},{"value":"1552-4930","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,9]]},"assertion":[{"value":"2018-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}