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We present TrackSOM, a novel method for delineating cellular populations and tracking their development over a time\u2010 or disease\u2010course cytometry datasets. We demonstrate TrackSOM\u2010enabled elucidation of the immune response to West Nile Virus infection in mice, uncovering heterogeneous subpopulations of immune cells and relating their functional evolution to disease severity. TrackSOM is easy to use, encompasses few parameters, is quick to execute, and enables an integrative and dynamic overview of the immune system kinetics that underlie disease progression and\/or resolution.<\/jats:p>","DOI":"10.1002\/cyto.a.24668","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T06:24:21Z","timestamp":1656311061000},"page":"54-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>TrackSOM<\/scp>\n                    : Mapping immune response dynamics through clustering of time\u2010course cytometry data"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7399-8014","authenticated-orcid":false,"given":"Givanna H.","family":"Putri","sequence":"first","affiliation":[{"name":"School of Computer Science The University of Sydney  Sydney New South Wales Australia"},{"name":"Charles Perkins Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Chung","sequence":"additional","affiliation":[{"name":"The Westmead Initiative The University of Sydney  Sydney New South Wales Australia"},{"name":"Viral Immunopathology Laboratory, Discipline of Pathology School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davis N.","family":"Edwards","sequence":"additional","affiliation":[{"name":"The Westmead Initiative The University of Sydney  Sydney New South Wales Australia"},{"name":"School of Medical Sciences, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-7628","authenticated-orcid":false,"given":"Felix","family":"Marsh\u2010Wakefield","sequence":"additional","affiliation":[{"name":"The Westmead Initiative The University of Sydney  Sydney New South Wales Australia"},{"name":"School of Medical Sciences, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Vascular Immunology Unit, Department of Pathology The University of Sydney  Sydney New South Wales Australia"},{"name":"Sydney Cytometry Core Research Facility The University of Sydney and Centenary Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-4187","authenticated-orcid":false,"given":"Irena","family":"Koprinska","sequence":"additional","affiliation":[{"name":"The Westmead Initiative The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suat","family":"Dervish","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-9772","authenticated-orcid":false,"given":"Nicholas J. 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