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Currently, no effective therapies exist for this ischemic complication, and the mechanisms driving left ventricular dilatation during chronic post\u2010infarction remodeling remain poorly understood. One potential pathological process leading to ventricular dilatation involves specific compensatory rearrangements in the border zone adjacent to the infarct, which isolates the intact myocardium from inflammation at the scar edge. Using a rat model, we examined ultrastructural changes in the intact and border zones of post\u2010infarction myocardium at chronic stages. Morphometric analysis of myofibrils, mitochondria, and excitation\u2010contraction coupling structures revealed similar remodeling processes in both zones at 2\u2009weeks post\u2010infarction, characterized by decreased myofibril density, reduced mitochondrial area and volume density, and shortened contacts between T\u2010tubules and sarcoplasmic reticulum. At 26\u2009weeks post\u2010infarction, during the dilated cardiomyopathy phase, we observed distinct compensatory changes in the border zone. Specifically, there was a loose arrangement of myofibrils and an increased volume fraction of mitochondria. These differences in remodeling between the intact and border zones highlight factors contributing to ventricular dilatation and help the development of new therapeutic strategies to delay heart failure progression in cardiac ischemia.<\/jats:p>","DOI":"10.1002\/cyto.a.24915","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T10:19:45Z","timestamp":1735640385000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrastructural Remodeling of Cardiomyocytes in Postinfarction Myocardium of Rats in the Late Stages of the Disease"],"prefix":"10.1002","volume":"107","author":[{"given":"Sergei A.","family":"Fedotov","sequence":"first","affiliation":[{"name":"Laboratory of Toxinology and Molecular Systematics L.A. Orbeli Institute of Physiology, National Academy of Sciences  Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Stepanov","sequence":"additional","affiliation":[{"name":"Group of Neuroregulation of Muscle Function Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences  St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina A.","family":"Sakuta","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan S.","family":"Andreev","sequence":"additional","affiliation":[{"name":"Group of Neuroregulation of Muscle Function Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences  St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina S.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Group of Neuroregulation of Muscle Function Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences  St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-9932","authenticated-orcid":false,"given":"Ekaterina V.","family":"Baidyuk","sequence":"additional","affiliation":[{"name":"Laboratory of Hyperspectral Imaging of Surgical Targets, Center of Excellence L.A. 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