{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:30:56Z","timestamp":1760297456204},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T00:00:00Z","timestamp":1111104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytologic discrimination of cellular nodules, follicular adenoma, and follicular carcinoma in the thyroid is problematic. Methods are needed to achieve a reliable diagnosis. Some sophisticated tools, such as microarrays, offer great potential but lack accompanying morphologic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred twelve samples obtained from patients with lesions histopathologically diagnosed as nodular goiter, follicular adenoma, follicular carcinoma, and papillary carcinoma were used. Eight geometric features, such as nuclear area and circular form factor, were measured. The dataset was divided into six overlapping groups to represent the frequently encountered situations in routine practice. Multivariate analysis of variance, Tukey's honestly significant differences test, and discriminant analysis were performed. Statistical analysis was carried out with two conceptually different approaches. In the first, data from all measured nuclei were used. In the second, a subset of data representing the most extreme values of variables was extracted from the entire dataset to simulate the \u201cselection procedure\u201d performed during conventional morphologic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When the selected dataset instead of data from all measured nuclei was used, the correct classification rates in discriminant analysis improved considerably.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Morphologic examination is based primarily on selection. Using data obtained from all of the cells in morphometry may cause a dilution effect in diagnostically important features. Morphometric studies may also be planned with a proper selection \u201cbias.\u201d This may be particularly helpful when isolated abnormal cells carry most of the diagnostic information. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.20024","type":"journal-article","created":{"date-parts":[[2005,3,19]],"date-time":"2005-03-19T12:04:57Z","timestamp":1111233897000},"page":"22-28","source":"Crossref","is-referenced-by-count":9,"title":["Contribution of morphometry in the differential diagnosis of fine\u2010needle thyroid aspirates"],"prefix":"10.1002","volume":"65B","author":[{"given":"Y\u0131ld\u0131r\u0131m","family":"Karsl\u0131o\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"Celasun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"G\u00fcnhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326594"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10355"},{"key":"e_1_2_6_4_2","first-page":"45","volume-title":"Manual of quantitative pathology in cancer diagnosis and prognosis","author":"Baak JP","year":"1991"},{"key":"e_1_2_6_5_2","first-page":"89","article-title":"The principles and advances of quantitative pathology","volume":"9","author":"Baak JP","year":"1987","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(87)80076-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1364\/AO.26.003270"},{"key":"e_1_2_6_8_2","series-title":"Ackerman's surgical pathology","first-page":"493","author":"Rosai J","year":"1996"},{"key":"e_1_2_6_9_2","first-page":"2665","volume-title":"Diagnostic cytology and its histopathologic basis","author":"Koss LG","year":"1992"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332683"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331147"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)41729-9"},{"key":"e_1_2_6_13_2","first-page":"507","article-title":"Karyometric analysis in the cytologic diagnosis of thyroid lesions","volume":"19","author":"Slowinska\u2010Klencka D","year":"1997","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80242-7"},{"key":"e_1_2_6_15_2","first-page":"437","article-title":"Morphometric studies on nuclei in smears of fine needle aspirates from oxyphilic tumors of the thyroid","volume":"27","author":"Bondeson L","year":"1983","journal-title":"Acta Cytol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332323"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(89)80226-2"},{"key":"e_1_2_6_18_2","first-page":"373","article-title":"Thyroid neoplasms. Can we do any better with quantitative cytology?","volume":"14","author":"Liautaud\u2010Roger F","year":"1992","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_6_19_2","first-page":"247","article-title":"Morphologic and planimetric diagnosis of follicular thyroid lesions on fine needle aspiration cytology","volume":"17","author":"Fadda G","year":"1995","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_6_20_2","first-page":"524","article-title":"Age\u2010related changes in the size of thyrocyte nuclei in aspirates from nontoxic nodular goiter","volume":"38","author":"Klencki M","year":"1994","journal-title":"Acta Cytol"},{"key":"e_1_2_6_21_2","first-page":"321","article-title":"Fine needle aspiration diagnosis of hyperplastic and neoplastic follicular nodules of the thyroid. A morphometric study","volume":"13","author":"Crissman JD","year":"1991","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.4.443"},{"key":"e_1_2_6_23_2","first-page":"195","article-title":"Differential diagnosis between follicular adenoma and follicular carcinoma of the thyroid by marker features","volume":"8","author":"Galera\u2010Davidson H","year":"1986","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_6_24_2","first-page":"47","article-title":"Comparison of morphonuclear features in normal, benign and neoplastic thyroid tissue by digital cell image analysis","volume":"14","author":"Salmon I","year":"1992","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_6_25_2","first-page":"72","article-title":"Morphometric analysis in the differential cytologic diagnosis of thyroid follicular lesions","volume":"16","author":"Shapiro N","year":"1994","journal-title":"Anal Quant Cytol Histol"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:52:26Z","timestamp":1697053946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,18]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/cyto.b.20024"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20024","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,18]]}}}