{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:33:03Z","timestamp":1789162383709,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T00:00:00Z","timestamp":1119398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this study we compared clinical findings with flow cytometric immunophenotypic results in a series of patients with aggressive and indolent gamma delta T\u2010cell malignancies with peripheral blood and\/or bone marrow involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gamma delta T\u2010cell malignancies were detected based on flow cytometric demonstration of an abnormal T\u2010cell population staining positive with T\u2010cell receptor gamma delta and confirmed by morphologic and clinical reviews. Clinical data were obtained through chart review and discussion with the patients' physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood or bone marrow involvement was present in all patients. Hepatosplenic and cutaneous gamma delta T\u2010cell lymphomas had an aggressive clinical course, whereas the gamma delta T\u2010cell large granular lymphocyte (LGL) leukemias had an indolent course. Expressions of CD5, CD8, CD16, and CD57 differed in gamma delta T\u2010cell LGL leukemia compared with hepatosplenic and cutaneous gamma delta T\u2010cell lymphomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gamma delta T\u2010cell malignancies have a poor prognosis with the exception of gamma delta T\u2010cell LGL leukemia (indolent process). Because CD57 expression is specific for gamma delta T\u2010cell LGL leukemias, expression of this antigen may be associated with a more indolent clinical course. Because cutaneous gamma delta T\u2010cell lymphoma can present with peripheral blood involvement, flow cytometric evaluation of peripheral blood is important in staging these patients. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.20063","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T21:47:20Z","timestamp":1119476840000},"page":"6-12","source":"Crossref","is-referenced-by-count":46,"title":["Flow cytometric immunophenotypic profiles of mature gamma delta T\u2010cell malignancies involving peripheral blood and bone marrow"],"prefix":"10.1002","volume":"67B","author":[{"given":"Ejaz","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Kingma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Schrager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Janik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyndham","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryalice","family":"Stetler\u2010Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.4.1277"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.4049\/jimmunol.143.8.2480","article-title":"Distribution of T cells bearing different forms of the T cell receptor gamma delta in normal and pathological human tissues","volume":"143","author":"Faini B","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V75.11.2213.2213","article-title":"Hepatosplenic T cell lymphoma: sinusal\/sinusoidal localization of malignant cells expressing the T\u2010cell receptor gamma delta","volume":"75","author":"Farcet JP","year":"1990","journal-title":"Blood"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4265.bloodjournal88114265"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401784"},{"key":"e_1_2_5_7_2","first-page":"1723","article-title":"Nonhepatosplenic gamma delta T\u2010cell lymphoma: a subset of cytotoxic lymphomas with mucosal or skin localization","volume":"91","author":"Arnulf B","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1024"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00893.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199408000-00014"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf293"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1992.tb00069.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1597"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00039.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000041073"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10480"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19961215)26:4<243::AID-CYTO2>3.0.CO;2-D"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20063","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T14:14:47Z","timestamp":1694614487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,22]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1002\/cyto.b.20063"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20063","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,22]]}}}