{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:04:54Z","timestamp":1760645094852},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T00:00:00Z","timestamp":1128470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastric and colorectal cancers belong to the most frequent cancer types in the world today. This fact emphasizes the importance of identification of useful diagnostic and prognostic markers, in the earliest stage of the disease. The examination of gene expression profile in gastric and colorectal cancer may develop the bases of early diagnosis and of individual therapeutic strategies. In the microarray examinations done so far for these types of cancers, the expression of hundreds and thousands of genes were studied, however, both the sample collection and the results showed wide variations. The diversity of expression array methods and data analysis makes the comparison of microarray results difficult. Beside the exposition of the practical aspects of the chip technology, our aims are the systematization of data that are currently available in the international scientific literature and the description of the results in a comprehensive way. Microarray results show that the gene expression pattern, detected in gastric and colon cancers, highly depends on the histological type and heterogeneity of the sample, array type, and softwares, used for data analysis. Recent experiments point out not just the changes of the alterations of tumor suppression, apoptosis, cell\u2010cycle regulation, and signal transduction, but tumor cell metabolism and cell\u2010microenvironment interactions also. Results show connection to and make more complete the already known molecular background of gastric and colorectal cancers. Based on the accumulation of recent and further data, such kind of multifunctional diagnostic microarrays that can be suited for completing the conventional histological diagnostics and subtypization will certainly become available in the near future. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cyto.b.20069","type":"journal-article","created":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T17:48:39Z","timestamp":1128534519000},"page":"1-17","source":"Crossref","is-referenced-by-count":6,"title":["The results of the expression array studies correlate and enhance the known genetic basis of gastric and colorectal cancer"],"prefix":"10.1002","volume":"68B","author":[{"given":"Orsolya","family":"Galamb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Sipos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Tulassay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,5]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910074"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308629"},{"key":"e_1_2_10_4_2","volume-title":"SEER Cancer Statistics Review, 1973\u20131997","author":"Ries LAG","year":"2000"},{"key":"e_1_2_10_5_2","first-page":"57","article-title":"Chronic inflammatory bowel disease and cancer","volume":"47","author":"Pohl C","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2889267"},{"key":"e_1_2_10_7_2","first-page":"4352","article-title":"Gene expression in colorectal cancer","volume":"62","author":"Birkenkamp\u2010Demtroder K","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/327298a0"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2649981"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8484122"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/5947"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/3260"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v8.i4.580"},{"issue":"1","key":"e_1_2_10_14_2","first-page":"20","article-title":"High density synthetic oligonucleotide arrays","volume":"21","author":"Lipshutz RJ","year":"1998","journal-title":"Nat Genet"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880476"},{"key":"e_1_2_10_16_2","first-page":"21","article-title":"DNA chips for gene expression analysis and their applications in diagnostics","volume":"144","author":"Galamb O","year":"2003","journal-title":"Orv Hetil"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-001-0370-7"},{"key":"e_1_2_10_18_2","first-page":"2569","article-title":"Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer","volume":"63","author":"Boussioutas A","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-12-0833"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1264"},{"key":"e_1_2_10_21_2","first-page":"7012","article-title":"Genome\u2010wide analysis of gene expression in intestinal\u2010type gastric cancers using a complementary DNA microarray representing 23,040 genes","volume":"62","author":"Hasegawa S","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_10_22_2","first-page":"233","article-title":"Global gene expression analysis of gastric cancer by oligonucleotide microarrays","volume":"62","author":"Hippo Y","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_10_23_2","first-page":"3475","article-title":"Prognostic score of gastric cancer determined by cDNA microarray","volume":"8","author":"Inoue H","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_24_2","first-page":"8248","article-title":"Expression profiling and subtype\u2010specific expression of stomach cancer","volume":"63","author":"Kim B","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00197-0"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00587-6"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.119292"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.01.022"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.7.513"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990909)82:6<868::AID-IJC16>3.0.CO;2-W"},{"key":"e_1_2_10_31_2","first-page":"287","article-title":"Garcia\u2010Foncillas dysregulation of apoptosis is a major mechanism in the lymph node involvement in colorectal carcinoma","volume":"12","author":"Bandres E","year":"2004","journal-title":"J Oncol Rep"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207262"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036848"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0396"},{"key":"e_1_2_10_35_2","article-title":"Common denominator genes that distinguish colorectal carcinoma from normal mucosa","author":"Croner RS","year":"2004","journal-title":"Int J Colorectal Dis"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-003-0434-x"},{"key":"e_1_2_10_37_2","first-page":"3544","article-title":"Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser\u2010capture microdissection of tumor tissues and normal epithelia","volume":"61","author":"Kitahara O","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0032-7"},{"key":"e_1_2_10_39_2","first-page":"305","article-title":"Genes associated with liver metastasis of colon cancer, identified by genome\u2010wide cDNA microarray","volume":"24","author":"Li M","year":"2004","journal-title":"Int J Oncol"},{"key":"e_1_2_10_40_2","first-page":"3124","article-title":"Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays","volume":"61","author":"Notterman DA","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234309"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.55.1.34"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.186"},{"key":"e_1_2_10_44_2","first-page":"931","article-title":"Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference","volume":"9","author":"Williams NS","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205613"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203820"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(01)04003-7"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10079"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0102rev"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1238::AID-CNCR5>3.0.CO;2-B"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01440.x"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91548-5"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006127621512"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.704"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011733"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981023)79:5<455::AID-IJC2>3.0.CO;2-#"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.1.109"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203650"},{"key":"e_1_2_10_59_2","first-page":"4158","article-title":"Loss of retinoic acid receptor \u03b2 expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer","volume":"57","author":"Widschwendter M","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.34.24425"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.7.4515"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10116.x"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.46.28823"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)80113-X"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202627"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004320000195"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0300207"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2820273"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5316.1268"},{"key":"e_1_2_10_70_2","first-page":"5151","article-title":"In vivo gene therapy with p53 or p21 adenovirus for prostate cancer","volume":"55","author":"Eastham JA","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/88800"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0395-249"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.43.30603"},{"key":"e_1_2_10_74_2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1139\/o98-095","article-title":"Recent advances in the molecular biology of nucleoside transporters of mammalian cells","volume":"76","author":"Cass CE","year":"1998","journal-title":"Biochem Cell Biol"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4872"},{"key":"e_1_2_10_76_2","first-page":"334","article-title":"Frequent nitric\u2010oxide synthase\u20102 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression","volume":"58","author":"Ambs S","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14224.x"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.6.1265"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90900-W"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900421"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690689"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:57:52Z","timestamp":1697043472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,5]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1002\/cyto.b.20069"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20069","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,5]]}}}