{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:01:54Z","timestamp":1791151314724,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The immunophenotypic features of angioimmunoblastic T\u2010cell lymphoma (AILT) have not been well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively reviewed our institutional experience with the flow cytometric features of 16 cases of AILT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Multiparameter flow cytometry was able to identify a distinct population of immunophenotypically aberrant T cells in 15 of 16 cases. In 13 lymph node specimens, the neoplastic cells ranged from 1.9 to 87% (median 23%) of cells. The ratio of reactive to neoplastic T cells ranged from 0.01 to 20 (median 1.5); reactive T cells outnumbered neoplastic in 9\/13 (69%) cases. The neoplastic populations expressed CD2, CD4, CD5, and CD45RO in all cases, lacked expression of CD8 and CD56 in all cases, and showed negative or dim surface CD3 in most cases. CD10 was expressed by the neoplastic populations in 11 of 14 cases at diagnosis; in 3 of these 11 only a subpopulation of the neoplastic cells was CD10(+). CD10 tended to be absent on neoplastic cells in staging bone marrows. The neoplastic population in all but one of the 15 positive cases possessed multiple immunophenotypic abnormalities and these were generally retained during the follow\u2010up analyses of several cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results indicate the potential utility of flow cytometry in the diagnosis and follow\u2010up of AILT. \u00a9 2006 International Society for Analytical Cytology<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cyto.b.20107","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T17:46:50Z","timestamp":1143654410000},"page":"142-148","source":"Crossref","is-referenced-by-count":41,"title":["Flow cytometric features of angioimmunoblastic T\u2010cell lymphoma"],"prefix":"10.1002","volume":"70B","author":[{"given":"Weina","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa V.","family":"Kesler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin J.","family":"Karandikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Kroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04335.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200209000-00001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90553-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501022920101"},{"key":"e_1_2_6_6_2","first-page":"30403","article-title":"Bcl\u20106 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T\u2010cell lymphoma with hyperplastic germinal centers: Heterogeneity of intrafollicular T\u2010cells and their altered distribution in the pathogenesis of angioimmunoblastic T\u2010cell lymphoma","author":"Ree HJ","year":"1999","journal-title":"Hum Pathol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.627"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/QF6N-VAQW-N74H-4JE2"},{"key":"e_1_2_6_9_2","first-page":"225","volume-title":"World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2498"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1309\/RM1Q-1T0B-WKQB-AF5A"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000084630.64243.D1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1309\/VD2D-98ME-MB3F-WH34"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880539"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0320(20000615)42:3<180::AID-CYTO4>3.0.CO;2-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00459"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10758"},{"key":"e_1_2_6_18_2","first-page":"271A","article-title":"Angioimmunoblastic T\u2010cell lymphoma: A neoplasm of intrafollicular CD10+, BCL\u20106+, CD4+ memory T\u2010cells?","volume":"15","author":"Yuan CM","year":"2002","journal-title":"Mod Pathol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200103000-00015"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00005"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:08:49Z","timestamp":1696968529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,29]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1002\/cyto.b.20107"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20107","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,29]]}}}