{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:01:03Z","timestamp":1781629263929,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,8,11]],"date-time":"2006-08-11T00:00:00Z","timestamp":1155254400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2006,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>ZAP\u201070 has become one of the most studied prognostic markers in Chronic Lymphocytic Leukemia (CLL). ZAP\u201070 is remarkable in many ways: ZAP\u201070 has been identified as the best discriminating gene between prognostically distinct CLL subtypes using large scale gene expression profiling; ZAP\u201070 has been shown to enhance signal transduction in CLL B\u2010cells and therefore could contribute to disease progression; and ZAP\u201070 is one of the rare examples of an intracellular target considered for clinical flow cytometry. This issue attests to the enormous effort and the steady progress made in overcoming technical challenges of testing for ZAP\u201070 expression and sets the foundation for a successful translation of this important marker into clinical practice. Despite the best effort, one will likely have to accept that not all cases can be clearly assigned to one or the other group, given that ZAP\u201070 expression between CLL patients falls along a continuum from absent to high. Nevertheless, ZAP\u201070 expression could become a key parameter to guide patients towards risk adapted treatment strategies in prospective clinical trials. \u00a9 2006 International Society for Analytical Cytology<\/jats:p>","DOI":"10.1002\/cyto.b.20126","type":"journal-article","created":{"date-parts":[[2006,8,12]],"date-time":"2006-08-12T00:16:54Z","timestamp":1155341814000},"page":"201-203","source":"Crossref","is-referenced-by-count":9,"title":["Flow cytometry for ZAP\u201070: New colors for chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"70B","author":[{"given":"Adrian","family":"Wiestner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,11]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"42","article-title":"Chronic lymphocytic leukemia: Staging and prognostic factors","volume":"25","author":"Zwiebel JA","year":"1998","journal-title":"Semin Oncol"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2281"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.1840"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.1848"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1410.h81602001410_1410_1416"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.11.1625"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.11.1639"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3306"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa023143"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15260-9"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040857"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403726"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1309\/WVQPVDF8UF7AV21X"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1715"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1718"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj120"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403707"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432602"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.10.861"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T05:20:39Z","timestamp":1694496039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,15]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7,15]]}},"alternative-id":["10.1002\/cyto.b.20126"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20126","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,15]]}}}