{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:59:14Z","timestamp":1761512354629},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Monoclonal B\u2010cells can be detected in the peripheral blood of some adults without B\u2010cell malignancies, a condition recently termed monoclonal B\u2010cell lymphocytosis (MBL). The risk of individuals with MBL progressing to a B\u2010cell malignancy is unknown. Polyclonal B\u2010cell lymphocytosis (PCBL) has not been systematically studied in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We obtained lymphocyte subset counts on 1,926 residential adults aged 40\u201376 years in a series of environmental health studies between 1991 and 1994. We then conducted two follow\u2010ups in 1997 and 2003 on consenting participants with B\u2010cell lymphocytosis, which included nine participants with MBL. To ascertain the clinical implications of MBL, we reviewed medical records and death certificates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The overall prevalence of MBL was 0.57% (11\/1,926): nine cases at baseline and two additional cases identified at follow\u2010up. Two (19%) MBL cases subsequently developed a B\u2010cell malignancy; MBL persisted in the remaining nine cases (81%). All PCBL cases where no clone emerged regressed to normal B\u2010cell counts over the follow\u2010up period. MBL was significantly more frequent in residents near a hazardous waste site than in the control populations (age\u2010adjusted OR 6.2; 95%CI 1.1\u201336.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>MBL confers an elevated risk for developing a B\u2010cell malignancy, although it occurs only in a minority of cases. PCBL is most often a transient state, but a monoclonal population can emerge and persist. Prospective studies are needed to distinguish stable from progressive forms of B\u2010cell lymphocytosis and to clarify the etiologic role of environmental exposures. Published 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.20174","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T05:47:34Z","timestamp":1170481654000},"page":"344-353","source":"Crossref","is-referenced-by-count":59,"title":["Prevalence and natural history of monoclonal and polyclonal B\u2010cell lymphocytosis in a residential adult population"],"prefix":"10.1002","volume":"72B","author":[{"given":"Youn K.","family":"Shim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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