{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:54:36Z","timestamp":1790175276587,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T00:00:00Z","timestamp":1202774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have demonstrated an increase in T\u2010regulatory cells in the involved lymph nodes and peripheral blood of patients with Hodgkin lymphoma. Our study examined whether the detection of T\u2010regulatory cells by flow cytometry could distinguish classical Hodgkin lymphoma (CHL) from benign cases and B\u2010cell non\u2010Hodgkin lymphomas (B\u2010NHL). We measured CD4, CD25, and CD152 in 14 CHLs, 2 nodular lymphocyte\u2010predominant Hodgkin lymphomas, 31 B\u2010NHLs, and 54 benign cases. All T\u2010regulatory cell parameters, including percent lymphocytes CD4+\/CD152+ and CD4+\/CD25+\/CD152+, and mean and median CD152 expression in CD4+\/CD25+ lymphocytes, were higher in CHL than in B\u2010NHL and benign. Mean CD152 in CD4+\/CD25+ lymphocytes distinguished CHL from benign with 79% sensitivity and 100% specificity, and from B\u2010NHL with 71% sensitivity and 90% specificity. Overall, our results show that T\u2010regulatory cells are increased in CHL and their detection may be a useful tool in differentiating CHL from other entities. \u00a9 2008 Clinical Cytometry Society<\/jats:p>","DOI":"10.1002\/cyto.b.20407","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T16:50:00Z","timestamp":1202835000000},"page":"227-235","source":"Crossref","is-referenced-by-count":34,"title":["Detection of T\u2010regulatory cells has a potential role in the diagnosis of classical Hodgkin lymphoma"],"prefix":"10.1002","volume":"74B","author":[{"given":"David S.","family":"Bosler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vonda K.","family":"Douglas\u2010Nikitin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie 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