{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T13:05:30Z","timestamp":1726405530756},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,7]],"date-time":"2008-04-07T00:00:00Z","timestamp":1207526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>The conjoint effect of HIV infection and pregnancy on the immune system of women submitted to the prophylactic antiretroviral therapy presently recommended is still poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We evaluated 44 HIV\u2010infected women (HIV) and 45 HIV\u2010negative women (CT) at parturition and we compared them to 20 healthy nonpregnant women (NP). Immunophenotyping of lymphocytes was done by four\u2010color flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>All HIV\u2010infected women received HAART during pregnancy and 56.8% had viral load &lt;50 copies\/mL at delivery. CD4+T cells\/mm<jats:sup>3<\/jats:sup> were lower in HIV (447) than CT (593) and NP (738) (<jats:italic>P<\/jats:italic> &lt; 0.05). CD8+T cells\/mm<jats:sup>3<\/jats:sup> were higher in HIV (799) than CT (384) and NP (395) (<jats:italic>P<\/jats:italic> &lt; 0.05). NK cells\/mm<jats:sup>3<\/jats:sup> were lower in HIV (146) than in CT (253) and NP (198) (<jats:italic>P<\/jats:italic> &lt; 0.05). CD38 expression on CD4+T and on CD8+T cells was higher in HIV (CD4:12.1; CD8:14.9) than in CT(CD4:9.2; CD8:10.2) and NP(CD4:8.6; CD8:6.0) (<jats:italic>P<\/jats:italic> &lt; 0.05). However, CD56 expression on CD8+T cells (a marker of cytolytic effector function) was lower in HIV(7%) than in CT(12%) and NP(9%) (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Even with low levels of viremia, HIV\u2010infected women at delivery showed a different immunologic profile from both healthy non\u2010HIV\u2010infected women in the puerperium and nonpregnant women, with lower CD4+T and higher CD8+T cells, high levels of CD38 expression, but low CD56 expression on CD8+T cells and low NK cell numbers. \u00a9 2008 Clinical Cytometry Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.20418","type":"journal-article","created":{"date-parts":[[2008,4,7]],"date-time":"2008-04-07T20:56:25Z","timestamp":1207601785000},"page":"236-243","source":"Crossref","is-referenced-by-count":4,"title":["Immunologic features of HIV\u20101\u2010infected women on HAART at delivery"],"prefix":"10.1002","volume":"74B","author":[{"given":"Erika","family":"Ono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lia M. N.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy M.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina C. de M.","family":"Succi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abes M.","family":"Amed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo","family":"Salom\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esper G.","family":"Kall\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Isabel","family":"de Moraes\u2010Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,7]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"UNAIDS. Overview of the global AIDS epidemic. In: Report on the global AIDS epidemic: executive summary. A UNAIDS 10th anniversary special edition. Switzerland UNAIDS\/WHO2006; pp 8\u201343. Available at:http:\/\/data.unaids.org\/pub\/globalReport\/2006\/2006_GR_CH02_en.pdfAccessed: May 3 2007."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112489"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000117083.33239.b5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/427287"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90235-D"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1317"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(97)00018-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0080"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3577"},{"key":"e_1_2_5_11_2","first-page":"187","article-title":"Hematologic complications of HIV infection","volume":"7","author":"Sloand E","year":"2005","journal-title":"AIDS Rev"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2005.12.001"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2004.00175.x"},{"key":"e_1_2_5_14_2","first-page":"243","volume-title":"Cellular and Molecular Immunology","author":"Abbas AK","year":"2003"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20558"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0703-839"},{"key":"e_1_2_5_17_2","first-page":"240","article-title":"Immunopathogenesis of HIV infection","volume":"121","author":"Paranjape RS","year":"2005","journal-title":"Indian J Med Res"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000153105.42455.c2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60745-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4341"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.8.5305"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.3.789"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/08892220151126643"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.00995.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb01307.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026439726053"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/35065118"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.3.1148"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.3892"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200305020-00002"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411033311801"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.12.1498"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20418","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T15:13:00Z","timestamp":1699974780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,7]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/cyto.b.20418"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20418","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"type":"print","value":"1552-4949"},{"type":"electronic","value":"1552-4957"}],"subject":[],"published":{"date-parts":[[2008,4,7]]}}}