{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:14:08Z","timestamp":1775729648192,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T00:00:00Z","timestamp":1217462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral T\u2010cell lymphomas are uncommon lymphomas that show T\u2010cell antigenic loss and clonal T\u2010cell receptor (TCR) gene rearrangement. Rare cases of T\u2010cell lymphomas with aberrant expression of CD20 have been described. However, CD19 coexpression in a mature T\u2010cell neoplasm has not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histology, immunohistochemistry (IHC), and PCR for TCR gene rearrangement were performed on an excised lymph node specimen and a subsequent fine needle aspiration (FNA) of an additional lymph node. Flow cytometry (FC) was performed on FNA and peripheral blood specimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lymph node's architecture was effaced by a diffuse atypical lymphoid proliferation that, by IHC, was positive for CD3, CD2, and CD43 and negative for CD4, CD5, CD8, TdT, CD1a, and B\u2010cell\u2010associated antigens PAX\u20105, CD20, and CD79a. A clonal TCR gene rearrangement was detected. FC was performed on a subsequent FNA, and peripheral blood specimen demonstrated an aberrant T\u2010cell population with expression of CD2, CD3, CD27, TCR \u03b1\/\u03b2, CD52, CD38, CD45, and CD26 (partial expression) and negative for CD4, CD5, CD7, CD8, CD10, CD30, and CD56. The aberrant T\u2010cell population also expressed bright CD19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using FC, we describe the first case of peripheral T\u2010cell lymphoma with aberrant coexpression of CD19. Published 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.20442","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T16:04:56Z","timestamp":1217520296000},"page":"142-149","source":"Crossref","is-referenced-by-count":32,"title":["Novel CD19 expression in a peripheral T cell lymphoma: A flow cytometry case report with morphologic correlation"],"prefix":"10.1002","volume":"76B","author":[{"given":"Kathryn","family":"Rizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryalice","family":"Stetler\u2010Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wyndham","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance M.","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,31]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"2001 IARC Press Lyon France World Health Organization Classification of Tumours ESHN Jaffe H Stein JW Vardiman Tumours of Haematopoietic and Lymphoid Tissues"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800276"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.841"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.4.483"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.011734"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1309\/HPYGFLNXKFBHDQEV"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880229"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880133"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990140212"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100297"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1454"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1865"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1309\/LG0Q0VXYBETJ4VHE"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800778"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:52:45Z","timestamp":1697039565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,31]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1002\/cyto.b.20442"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20442","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,31]]}}}