{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:44Z","timestamp":1760244944379},"reference-count":23,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:00:00Z","timestamp":1277078400000},"content-version":"vor","delay-in-days":171,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>The pathology and clinical course of patients with CD5+ chronic B\u2010cell lymphoproliferative disorders, excluding those that present with typical chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL) or mantle cell lymphoma, (i.e. CD5+B\u2010CLPD) are poorly defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We studied patients with CD5+B\u2010CLPD to (1) more completely define the clinical features and pathology of CD5+B\u2010CLPD, (2) compare these features to patients presenting with typical CLL, and (3) test the hypothesis that a subset of patients with CD5+B\u2010CLPD could have a unique B\u2010cell malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>We identified 229 patients with CD5+B\u2010CLPD. A definitive pathological diagnosis was made in all 61 (27%) CD5+B\u2010CLPD patients with nonbone marrow (BM) biopsy specimens considered adequate for a comprehensive pathological examination. The most common diagnosis among these 61 patients was CLL (44%) followed by the leukemic phase of marginal zone lymphoma (34%), lymphoplasmacytic lymphoma (11%), diffuse large B cell lymphoma (8%), and high\u2010grade B cell lymphoma not otherwise specified (2%). In contrast, among 168 patients without a non\u2010BM tissue biopsy specimen, a specific diagnosis could be made on review of all available data in only 24 (14%) with 144 (86%) remaining \u201cunclassified.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In patients with CD5+B\u2010CLPD, a definitive diagnosis can be made on an adequate non\u2010BM tissue biopsy suggesting that this entity does not include a novel disease. We recommend that all patients with CD5+B\u2010CLPD should have a non\u2010BM tissue biopsy to make a definitive diagnosis prior to initiation of treatment. \u00a9 2010 International Clinical Cytometry Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.20546","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T18:24:57Z","timestamp":1277144697000},"source":"Crossref","is-referenced-by-count":21,"title":["CD5\u2010positive chronic B\u2010cell lymphoproliferative disorders: Diagnosis and prognosis of a heterogeneous disease entity"],"prefix":"10.1002","volume":"78B","author":[{"given":"Roxana S.","family":"Dronca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Jevremovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis A.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari G.","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tait D.","family":"Shanafelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Morice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Call","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil E.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Schwager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive S.","family":"Zent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010901)92:5<1325::AID-CNCR1454>3.0.CO;2-E"},{"key":"e_1_2_5_3_2","first-page":"1640","article-title":"The immunological profile of B\u2010cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"8","author":"Matutes E","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.4065\/83.7.776"},{"key":"e_1_2_5_5_2","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21188"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600727939"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600758660"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05548.x"},{"key":"e_1_2_5_10_2","first-page":"180","volume-title":"WHO Classification of Tumors of Haematopoietic and Lymphoid Tissue","author":"Muller\u2010Hermelink HK","year":"2008"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.03.020"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04265.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07086.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05550.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093906"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432602"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.4.378"},{"key":"e_1_2_5_18_2","series-title":"H43\u2010A2 Clinical Flow Cytometric Analysis of Neoplastic Hematolymphoid Cells; 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