{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:48:16Z","timestamp":1778525296060,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T00:00:00Z","timestamp":1290211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Occasional marginal zone lymphomas have extensive plasmacytic differentiation (P\u2010MZL). We present an argument based on our data and previous published observations that P\u2010MZL represent neoplasms of precursor plasma cells. Five P\u2010MZL were analyzed by flow cytometry and the phenotype was compared with conventional MZL, plasma cell myeloma (PCM), reactive plasmacytoses (RP), and normal marrow plasma cells. The clonal cells in four of five P\u2010MZL were CD19(+), CD20(dim\/\u2212), CD38(bright), CD45(++), CD56(\u2212), CD138(\u2212), and surface light chain(dim\/\u2212). One case was CD56(+), CD138(+), and CD19(\u2212). A separate clonal mature B cell population [CD20(+), CD79b(+)] was not detected in any of these tumors. Hierarchical clustering demonstrated similarity between the neoplastic cells in four of the five P\u2010MZL with plasma cells in RP comprised of precursor plasma cells. Analysis of normal bone marrow plasma cells revealed a CD45(++)CD38(bright)CD19(+)CD138(\u2212\/+) precursor plasma cell population similar to the plasma cells in RP and P\u2010MZL and a very small population of mature CD45(+\/\u2212)CD38(bright)CD138(+)CD19(\u2212) plasma cells resembling the neoplastic cells in PCM. The findings suggest that P\u2010MZL represents a malignancy of a plasma cell stage of differentiation distinct from the plasma cell stage corresponding to PCM. We propose the term precursor plasma cell neoplasm for these tumors. \u00a92010 International Clinical Cytometry Society<\/jats:p>","DOI":"10.1002\/cyto.b.20571","type":"journal-article","created":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T18:38:34Z","timestamp":1290278314000},"page":"71-82","source":"Crossref","is-referenced-by-count":12,"title":["Marginal zone B cell lymphomas with extensive plasmacytic differentiation are neoplasms of precursor plasma cells"],"prefix":"10.1002","volume":"80B","author":[{"given":"Howard J.","family":"Meyerson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Miedler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Olobatuyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,20]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.07.011"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199901000-00006"},{"key":"e_1_2_6_5_2","first-page":"S38","article-title":"Primary cutaneous marginal zone B\u2010cell lymphoma","volume":"125","author":"Cho\u2010Vega JH","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-2570(03)00012-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20426"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.154"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199211000-00005"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2002.1101206.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20086"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1309\/5EL22BH45PHUPM8P"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1680"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.1.111"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.701"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2003.12.001"},{"key":"e_1_2_6_17_2","first-page":"1234","article-title":"The phenotype of normal, reactive and malignant plasma cells. Identification of \u201cmany and multiple myelomas\u201d and of new targets for myeloma therapy","volume":"91","author":"Bataille R","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2507"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1113.h81602001113_1113_1122"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.2154"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3161"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126781.87158.e3"},{"key":"e_1_2_6_23_2","first-page":"2","article-title":"ALK\u2010positive diffuse large B\u2010cell lymphoma: Report of four cases and review of the literature","author":"Beltran B","year":"2009","journal-title":"J Hematol Oncol"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06879.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.300835.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.72653.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1309\/74R4TB90BUWH27JX"},{"key":"e_1_2_6_28_2","first-page":"200","article-title":"Indolent lymphoplasmacytic and marginal zone B\u2010cell lymphomas: Absence of both IRF4 and Ki67 expression identifies a better prognosis subgroup","volume":"90","author":"Petit B","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_29_2","first-page":"927","article-title":"Cyclin D1 protein in multiple myeloma and plasmacytoma: An immunohistochemical study using fixed, paraffin\u2010embedded tissue sections","volume":"10","author":"Vasef MA","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100140253"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19960315)26:1<16::AID-CYTO3>3.0.CO;2-E"},{"key":"e_1_2_6_32_2","volume-title":"CAP FL3 Survey Results Booklet","author":"Carey J","year":"2009"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20387"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0803"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2002.n.010"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2216"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11080"},{"key":"e_1_2_6_38_2","first-page":"49","article-title":"Hyaline\u2010vascular type of Castleman's disease (angiofollicular lymph node hyperplasia) with monotypic plasma cells. An immunohistochemical study with monoclonal antibodies","volume":"2","author":"Chilosi M","year":"1987","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00469.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199501000-00002"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199711000-00012"},{"key":"e_1_2_6_42_2","unstructured":"Available at:http:\/\/www.clevelandclinicmeded.com\/live\/courses\/2009\/Hemepath09\/index.asp"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2365"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603279"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.016"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.34"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50074"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.20571","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.20571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T09:26:14Z","timestamp":1697016374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.20571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,20]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/cyto.b.20571"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.20571","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,20]]}}}