{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T16:32:58Z","timestamp":1724171578728},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mixed phenotypic acute leukemia (MPAL) is a rare disorder with an incidence of less than 2% of all acute leukemia using the recent 2008 WHO criteria. Common subtypes encountered are the B\/myeloid and T\/myeloid; B\/T or trilineage MPAL being an exception. We discuss here a case of 20\u2010year\u2010male patient who presented with pallor and generalised lymphadenopathy. Peripheral blood smear examination showed presence of 61% blasts of lymphoid morphology. Immunophenotyping by multicolor flow cytometry showed two distinct populations of blasts with T and B phenotype respectively. He was diagnosed as MPAL with two distinct blast lineages. Conventional karyotyping done on bone marrow sample showed t(9;22)(q34;q11)(Ph +). Induction was started using ALL based protocol. The patient is on follow up with post induction marrow being in morphological remission. \u00a9 2013 International Clinical Cytometry Society<\/jats:p>","DOI":"10.1002\/cyto.b.21086","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T13:48:55Z","timestamp":1362750535000},"page":"198-201","source":"Crossref","is-referenced-by-count":5,"title":["Mixed phenotypic acute leukemia with two immunophenotypically distinct blast populations: Report of an unusual case"],"prefix":"10.1002","volume":"84B","author":[{"given":"Khaliqur","family":"Rahman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seena","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apoorvi","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404848"},{"key":"e_1_2_4_3_2","first-page":"699","article-title":"Outcome of biphenotypic acute leukemia","volume":"84","author":"Killick S","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.003202"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-187351"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701843247"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00523.x"},{"key":"e_1_2_4_8_2","first-page":"150","volume-title":"WHO classification of hematopoietic and lymphoid tissue","author":"Borowitz MJ","year":"2008"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.202"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-314682"},{"key":"e_1_2_4_11_2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1182\/blood.V66.5.1115.1115","article-title":"Acute Mixed lineage leukemia: Clinicopathologic correlation and prognostic significance","volume":"66","author":"Mirro J","year":"1985","journal-title":"Blood"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20607"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20586"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20565"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20484"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01714978"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri721"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.02.004"},{"key":"e_1_2_4_19_2","first-page":"213","article-title":"Bipheotypic acute leukemia","volume":"138","author":"Aribi A","year":"2007","journal-title":"Hematology"}],"container-title":["Cytometry Part B: Clinical Cytometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcyto.b.21086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cyto.b.21086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T16:34:25Z","timestamp":1696955665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cyto.b.21086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,8]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1002\/cyto.b.21086"],"URL":"https:\/\/doi.org\/10.1002\/cyto.b.21086","archive":["Portico"],"relation":{},"ISSN":["1552-4949","1552-4957"],"issn-type":[{"value":"1552-4949","type":"print"},{"value":"1552-4957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,8]]}}}