{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:08:39Z","timestamp":1791220119277,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The expression of the immunoglobulin superfamily cell membrane adhesion molecule CD146 has been reported on several normal and pathological cell types in human. The aim of this study was to investigate CD146 expression in acute leukemia using a multiparametric cytofluorimetric approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cytofluorimetric and cytogenetic studies were performed on peripheral blood and bone marrow samples from 162 patients with acute myeloid leukemia (AML,<jats:italic>n<\/jats:italic>\u2009=\u2009121) and acute lymphoblastic leukemia (ALL,<jats:italic>n<\/jats:italic>\u2009=\u200941). ALL patients were subdivided in B\u2010ALL (<jats:italic>n<\/jats:italic>\u2009=\u200938) and T\u2010ALL (<jats:italic>n<\/jats:italic>\u2009=\u20093). Adult (<jats:italic>n<\/jats:italic>\u2009=\u200918) and pediatric (<jats:italic>n<\/jats:italic>\u2009=\u200920) B\u2010ALL were considered as a whole group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four out of 121 (3.3%) AML cases, 14\/38 (36.8%) B\u2010ALL, and 2\/3 (66.6%) T\u2010ALL expressed CD146 on 12\u201398% of blasts (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). CD146 expression was not observed in 10 healthy controls. Among B\u2010ALL CD146\u2010positive cases, 78.6% were associated with a \u201ccommon\u201d\/BII\u2010ALL and 21.4% with a pre\u2010B\/BIII\u2010ALL immunophenotype while pro\u2010B\/BI\u2010ALL and mature\u2010B\/BIV\u2010ALL cases were CD146\u2010negative. Statistical analysis showed CD146 expression strongly associated with Ph+ positivity in B\u2010ALL with the highest percentage of CD146\u2010positive blasts in all Ph\u2010positive B\u2010ALL cases (84\u2009\u00b1\u200922% Ph\u2010positive B\u2010ALL SD vs. 40\u2009\u00b1\u200924% SD in Ph\u2010negative B\u2010ALL;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090,001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our series, CD146 was expressed in all cases of Ph\u2010positive B\u2010ALL and in the vast majority of T\u2010ALL, whereas it was rarely expressed by AML blasts. We suggest that CD146 may be considered as an additional marker for acute lymphoblastic leukemia diagnosis and monitoring of minimal residual disease in those cases which are CD146\u2010positive at diagnosis. \u00a9 2015 International Clinical Cytometry Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.21267","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T16:11:41Z","timestamp":1435075901000},"page":"247-256","source":"Crossref","is-referenced-by-count":6,"title":["Expression of the immunoglobulin superfamily cell membrane adhesion molecule Cd146 in acute leukemia"],"prefix":"10.1002","volume":"90","author":[{"given":"Francesco","family":"Cavazzini","sequence":"first","affiliation":[{"name":"Section of Hematology University\u2010S.Anna Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Campioni","sequence":"additional","affiliation":[{"name":"Section of Hematology University\u2010S.Anna 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Cristina","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Section of Hematology Hospital of Cremona Cremona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuele","family":"Ongari","sequence":"additional","affiliation":[{"name":"Section of Hematology Hospital of Cremona Cremona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Dabusti","sequence":"additional","affiliation":[{"name":"Section of Hematology University\u2010S.Anna Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Daghia","sequence":"additional","affiliation":[{"name":"Section of Hematology University\u2010S.Anna Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Sofritti","sequence":"additional","affiliation":[{"name":"Section of Hematology University\u2010S.Anna Hospital Ferrara 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