{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T17:29:23Z","timestamp":1750958963044},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Eskisehir Osmangazi University Scientific Research Committee","award":["2013-255"],"award-info":[{"award-number":["2013-255"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Regulatory T cells (Tregs) are a specialized subpopulation of CD4+ T cells which maintain the immune system homeostasis. They may increase during cancer progression and have been correlated with a worse prognosis in many malignancies. However, the role of Treg cells in lymphoma is debated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we assessed the peripheral blood levels of CD4+ CD25+ FOXP3+ Tregs in newly diagnosed patients with lymphoma and tried to find a relationship with patient characteristics. Twenty one patients with Hodgkin lymphoma (HL), 40 patients with non Hodgkin lymphoma (NHL) and 30 healthy sex matched controls were included in the study. Analysis were done by 3\u2010color flow cytometry and only helper T cells were selected directly using CD4perCP as a gating strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In HL group; there was a positive correlation with IPS, CRP, LDH and negative correlation with albumin, absolute lymphocyte count. Tregs were higher in male HL patients. In NHL group; there was a positive correlation with stage, IPI, CRP, LDH and a negative correlation with albumin ve absolute lymphocyte count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a relationship between peripheral blood Treg levels and some poor prognostic parameters in newly diagnosed lymphoma patients. This relationship suggests a possible prognostic role of Tregs in lymphoma. Further research is needed in determining how to use Tregs as a prognostic factor. \u00a9 2015 International Clinical Cytometry Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.21330","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T09:16:39Z","timestamp":1444209399000},"page":"449-454","source":"Crossref","is-referenced-by-count":13,"title":["Peripheral blood regulatory<scp>T<\/scp>cell levels are correlated with some poor prognostic markers in newly diagnosed lymphoma patients"],"prefix":"10.1002","volume":"90","author":[{"given":"Eren","family":"Gunduz","sequence":"first","affiliation":[{"name":"Department of Hematology Eskisehir Osmangazi University School of Medicine Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Sermet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eskisehir Osmangazi University School of Medicine Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Musmul","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , Eskisehir Osmangazi University School of Medicine Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2741\/3657"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1093"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2363"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1002\/cncr.24999","article-title":"Intratumoral forkhead box P3\u2010positive regulatory T cells predict poor survival in cylooxygenase\u20102\u2010positive uveal melanoma","volume":"16","author":"Mougiakakos D","year":"2010","journal-title":"Cancer"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-4-50"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20471"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunolog\u0131c self\u2010tolerance maintained by activeted T cells expressing IL\u20102 receptor alpha\u2010chains (CD25). 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