{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:38:43Z","timestamp":1721111923078},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>We determined the normal level and phenotype of CD1c(+) myeloid dendritic cells (MDCs) in blood and bone marrow and evaluated the level of CD1c(+) MDCs in 295 myeloid neoplasms. CD1c(+) MDCs were increased above the mean level of non\u2010neoplastic hospital controls in 18.0% (53\/295) of myeloid malignancies, increased three standard deviations above the control mean in 14.2% (42\/295) with a 10\u2010fold or more increase compared to mean in 6.8% (20\/295). Increased CD1c(+) MDCs were associated with chronic myelomonocytic leukemia (CMML) (12\/24, 50%) and acute myeloid leukemia (AML) (31\/140, 22%) with a strong association with AML with the inv(16) cytogenetic abnormality. The cells were not increased in chronic myelogenous leukemia (CML) and rarely increased in non\u2010CML myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). Immunohistochemical staining of cases with increased CD1c(+) MDCs did not reveal clustering of the cells unlike that observed with myeloid neoplasms associated with increased plasmacytoid dendritic cells. Our findings indicate CD1c(+) MDC elevations are not uncommon in myeloid leukemias and are associated with CMML and AML, particularly AML with inv(16). \u00a9 2015 International Clinical Cytometry Society<\/jats:p>","DOI":"10.1002\/cyto.b.21332","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:02:41Z","timestamp":1445904161000},"page":"337-348","source":"Crossref","is-referenced-by-count":13,"title":["CD1c(+) myeloid dendritic cells in myeloid neoplasia"],"prefix":"10.1002","volume":"90","author":[{"given":"Howard J.","family":"Meyerson","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospitals Case Medical Center and Seidman Cancer Center Case Western Reserve University Cleveland Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebenezer","family":"Osei","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospitals Case Medical Center and Seidman Cancer 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