{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:52:26Z","timestamp":1747147946770,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of CD200 in the differential diagnosis of chronic lymphocytic leukemia (CLL) and classical mantle cell lymphoma (MCL) is well established. Its role in the differential diagnosis of CLL and other lymphoproliferative disorders (LPD) is less clear, in particular its positive predictive value (PPV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a systematic review of the use of CD200 in the differential diagnosis of CLL, MCL, and other predominantly leukemic, typically CD103\u2010negative LPD. With the results, we then derived a curve to determine the PPV based on the prevalence of the disorders included in the differential diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 43 publications screened, 27 were included in the systematic review (5,764 patients). The median CD200 positivity rate in all studies and the percentage of CD200\u2010positive (pooled) patients was 100% and 95% (3,061\/3,208) in CLL, 4 and 8% (86\/1112) in MCL and 56 and 62% (425\/689) in other LPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CD200 is suboptimal for the differential diagnosis of CLL and disorders other than nodal MCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.21849","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T10:44:03Z","timestamp":1573037043000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Positive predictive value of CD200 positivity in the differential diagnosis of chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-591X","authenticated-orcid":false,"given":"Marc","family":"Sorigue","sequence":"first","affiliation":[{"name":"Hematology Laboratory, ICO\u2010Hospital Germans Trias i Pujol. IJC Universitat Aut\u00f2noma de Barcelona  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Magnano","sequence":"additional","affiliation":[{"name":"Hematopathology Unit, Department of Pathology Hospital Clinic de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos D.","family":"Miljkovic","sequence":"additional","affiliation":[{"name":"Lymphoid Malignancies Branch National Cancer Institute  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Nieto\u2010Moragas","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Hospital Dr Josep Trueta  Girona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireia","family":"Santos\u2010Gomez","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, ICO\u2010Hospital Germans Trias i Pujol. 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