{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:36:13Z","timestamp":1788413773071,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphocytic variant of hypereosinophilic syndrome (L\u2010HES) is a subtype of HES driven by cytokines produced by clonal T\u2010cells. Due to the rarity of its occurrence and challenges in diagnosis, this subtype of HES is under recognized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We report seven patients with L\u2010HES, diagnosed from a group of 136 patients who were referred to our institution for the work\u2010up of hypereosinophilia. The clinical presentation, symptoms and signs were heterogeneous and uncharacteristic; indistinguishable from idiopathic HES. Flow cytometry immunophenotypic analysis revealed aberrant T\u2010cells in all patients, with a Th2 immunophenotype, CD2\u2009+\u2009CD3\u2212CD4\u2009+\u2009CD5\u2009+\u2009CD7dim+\/\u2212CD8\u2212 in six of seven (86%) cases. CD10 was partially expressed in one of seven (14%) cases, and clonal <jats:italic>TCR<\/jats:italic> gene rearrangement was detected by PCR in five of seven (71%) patients. All patients were treated with corticosteroids and two of seven (29%) patients received anti\u2010IL5 antibody therapy. With a median follow\u2010up time of 7.5\u2009years (2.3\u201314.1\u2009years), one (11%) patient developed peripheral T\u2010cell lymphoma 6.1\u2009years after the initial diagnosis of L\u2010HES and responded well to chemotherapy. All patients were alive at the last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, a combination of flow cytometry immunophenotyping and molecular analysis allows the identification of aberrant T\u2010cells, facilitating a diagnosis of L\u2010HES in patients with eosinophilia. A correct diagnosis is essential for the proper management of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cyto.b.21874","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T08:42:57Z","timestamp":1583916177000},"page":"352-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Lymphocytic variant of hypereosinophilic syndrome: A report of seven cases from a single institution"],"prefix":"10.1002","volume":"100","author":[{"given":"Zhihong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Texas Health Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center  Houston Texas 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