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The following key points are raised: (a) S\u00e9zary syndrome and mycosis fungoides cells most often have a characteristic CD3+ CD4+ CD7\u2212 and\/or CD26\u2212 immunophenotype. (b) This immunophenotype is not specific, but can assist in the distinction from non\u2010neoplastic T cells and other subtypes of mature T\u2010cell neoplasm. (c) However, small subsets of normal and reactive T\u2010cells can have an overlapping immunophenotype, and can be distinguished by evaluating for additional changes in antigen expression.<\/jats:p>","DOI":"10.1002\/cyto.b.21888","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T16:56:23Z","timestamp":1591721783000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["S\u00e9zary syndrome and mycosis fungoides: An overview, including the role of immunophenotyping"],"prefix":"10.1002","volume":"100","author":[{"given":"Melissa P.","family":"Pulitzer","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Horna","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3124-8917","authenticated-orcid":false,"given":"Julia","family":"Almeida","sequence":"additional","affiliation":[{"name":"Cancer Research Center (IBMCC\u2010CSIC\/USAL), Cytometry Service (NUCLEUS) and Department of Medicine University of Salamanca, IBSAL and CIBERONC  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1698-8"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04014.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.01.038"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000258"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00495.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-251926"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181bf677d"},{"key":"e_1_2_3_9_1","volume-title":"WHO classification of skin tumours","author":"Elder D. 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