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With the exception of primary mediastinal large B cell lymphoma, these lymphomas have similar morphologic growth patterns with occasional neoplastic cells within a prominent reactive cell background. Historically, distinguishing these entities was difficult by flow cytometry; however, over the past 15\u2009years, our laboratory has developed antibody\u2010fluorochrome combinations capable of accurately distinguishing these entities by their immunoprofile. Additionally, an algorithmic approach based on characterization of the background reactive B\u2010cell and T\u2010cell populations can aid in narrowing the differential diagnosis. This review summarizes both the morphologic and immunophenotypic features and the current flow cytometric insights of the neoplastic and reactive populations found in this unique subset of lymphomas.<\/jats:p>","DOI":"10.1002\/cyto.b.22045","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T11:26:17Z","timestamp":1638962777000},"page":"14-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A comparison and review of the flow cytometric findings in classic Hodgkin lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, T cell\/histiocyte rich large B cell lymphoma, and primary mediastinal large B cell lymphoma"],"prefix":"10.1002","volume":"102","author":[{"given":"Daniel S.","family":"Martig","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Fromm","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-4-384"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-024109"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24485"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20407"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080809"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.659"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-204065"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21544"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqv017"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.74"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.01.002"},{"issue":"22","key":"e_1_2_6_13_1","first-page":"133","article-title":"HLA\u2010DR protein expression correlates with non\u2010neoplastic T\u2010cell infiltration and predicts survival in patients with primary mediastinal large B\u2010cell lymphoma (PMBCL) treated with CHOP chemotherapy","volume":"114","author":"Farinha P.","year":"2009","journal-title":"ASH Annual Meeting Abstracts"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01466.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1309\/7371XK6F6P7474XX"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPW3UN9DYLDSPB"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20535"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.10.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2012.03.028"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP0Q1SVOXBHMAM"},{"key":"e_1_2_6_21_1","first-page":"314","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Gaulard P. 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