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This retrospective study aimed to evaluate the prognostic relevance of the end of induction MRD in B\u2010cell acute lymphoblastic leukemia (B ALL) patients. The study included 481 patients who underwent treatment for B ALL between August 2012 and March 2019 and had their MRD at the end of induction assessed by flow cytometry. Baseline demographic characteristics were collected from the patient's clinical records. Event free survival (EFS) and relapse free survival (RFS) were calculated using Kaplan\u2013Meier analysis and survival estimates were compared using the log\u2010rank test. End of induction MRD and baseline karyotype were the strongest predictors of EFS and RFS on multivariate analysis. The EFS was inversely related to the MRD value and the outcomes were similar in patients without morphological remission at the end of induction and patients in remission with MRD \u22651.0%. Even within the subgroups of ALL based on age, karyotype, <jats:italic>BCR::ABL1<\/jats:italic> translocation and the treatment protocol, end of induction MRD positive patients had poor outcomes compared to patients who were MRD negative. The study outcome would help draft end of induction MRD\u2010based treatment guidelines for the management of B ALL patients.<\/jats:p>","DOI":"10.1002\/cyto.b.22139","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T09:51:13Z","timestamp":1691574673000},"page":"440-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical significance of end of induction measurable residual disease monitoring in B\u2010cell acute lymphoblastic leukemia: A single center experience"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0362-0278","authenticated-orcid":false,"given":"Arun Kumar","family":"Arunachalam","sequence":"first","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore 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