{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:50:07Z","timestamp":1789206607408,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970140"],"award-info":[{"award-number":["81970140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370161"],"award-info":[{"award-number":["82370161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytometry Part B Clinical"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We investigated the prognostic value of aberrant lymphoblasts (ALB) detected by flow cytometry (FCM) for predicting lymphoid transformation in patients with newly diagnosed chronic myeloid leukemia (CML). Data from patients with chronic phase CML were retrospectively interrogated to analyze covariates associated with lymphoid transformation\u2010free survival (LTFS) via Cox, Firth\u2010penalized Cox, Inverse Probability of Treatment Weighting\u2010weighted Cox, and Fine\u2010Gray competing risk regression approaches. Among 1081 patients, with a median follow\u2010up of 43 (IQR, 16\u201370) months, 84 (8%) transformed to lymphoid or myeloid blast phase (LBP, 3%; MBP, 5%). 5\u2010year cumulative incidence of lymphoid transformation and probabilities of LTFS, transformation\u2010free survival and survival were 4% (95% CI, 3%\u20135%), 96% (95%\u201397%), 91% (89%\u201393%), and 95% (93%\u201396%), respectively. In the 54 patients (5%) with detectable ALB (median 0.3%; IQR, 0.1%\u20131.1%) at diagnosis, 24 (44%) transformed to LBP, none transformed to MBP. 0.4% ALB was identified as the optimal cutoff for LTFS by X\u2010tile analysis and the maximally selected rank statistics method. All patients were stratified into ALB low\u2010 (ALB\u2009=\u20090), intermediate\u2010 (0&lt; ALB &lt;\u20090.4%), and high\u2010risk (ALB \u22650.4%) groups with significant differences in 5\u2010year probabilities of lymphoid transformation (2% [95% CI, 1%\u20132%] vs. 18% [3%\u201332%] vs. 91% [70%\u2013100%];\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001) and LTFS (98% [98%\u201399%] vs. 82% [69%\u201398%] vs. 9% [2%\u201349%];\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001). Multivariable analyses confirmed that ALB intermediate\u2010\/high\u2010risk groups and higher white blood cell count at diagnosis were significantly associated with a higher likelihood of lymphoid transformation. Low\u2010level ALB detected by FCM at diagnosis identifies patients with chronic phase CML at high risk for lymphoid transformation, especially those with ALB \u22650.4%.\n                  <\/jats:p>","DOI":"10.1002\/cyto.b.70046","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:53:23Z","timestamp":1782190403000},"page":"335-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["What is the optimal threshold for aberrant lymphoblasts at diagnosis to predict lymphoid transformation in chronic myeloid leukemia?"],"prefix":"10.1002","volume":"110","author":[{"given":"Zhenzhen","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hematology Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhen","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0774-973X","authenticated-orcid":false,"given":"Yazhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-0522","authenticated-orcid":false,"given":"Qian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"},{"name":"Department of Hematology Peking University People's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"issue":"10","key":"e_1_2_10_3_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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