{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:24:51Z","timestamp":1791066291254,"version":"4.1.0"},"reference-count":20,"publisher":"Hindawi Limited","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2465,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Depress. Anxiety"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1002\/da.20540","type":"journal-article","created":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T23:49:25Z","timestamp":1228434565000},"page":"989-992","source":"Crossref","is-referenced-by-count":43,"title":["Treatment-resistant depression: recent developments and future directions"],"prefix":"10.1155","volume":"25","author":[{"given":"Sanjay J.","family":"Mathew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"10.1002\/da.20540-BIB1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0006-3223(03)00088-X","article-title":"Research issues in the study of difficult-to-treat depression","volume":"53","author":"Rush","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20540-BIB2","unstructured":"European Agency for the Evaluation of Medicinal Products. Evaluation of Medicines for Human Use. Note for Guidance on Clinical Investigation of Medicinal Products in the Treatment of Depression 2002. London, England. Available at: http:\/\/www.emea.europa.eu\/pdfs\/human\/ewp\/051897en.pdf."},{"key":"10.1002\/da.20540-BIB3","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4088\/JCP.v68n0713","article-title":"Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study","volume":"68","author":"Souery","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1002\/da.20540-BIB4","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMoa052963","article-title":"Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression","volume":"354","author":"Rush","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1002\/da.20540-BIB5","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1038\/sj.npp.1301390","article-title":"Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR*D measurement-based care","volume":"32","author":"Trivedi","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/da.20540-BIB6","unstructured":"Deplin package insert. Available at: http:\/\/www.deplin.com\/media\/Deplin_PackageInsert.pdf."},{"key":"10.1002\/da.20540-BIB7","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0140-6736(03)12705-5","article-title":"Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis","volume":"361","author":"UK ECT Review Group","year":"2003","journal-title":"Lancet"},{"key":"10.1002\/da.20540-BIB8","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.biopsych.2007.01.018","article-title":"Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial","volume":"62","author":"O'Reardon","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20540-BIB9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.4088\/JCP.v68n0604","article-title":"The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study","volume":"68","author":"Berman","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1002\/da.20540-BIB10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.biopsych.2003.09.015","article-title":"Effectiveness of electroconvulsive therapy in community settings","volume":"55","author":"Prudic","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20540-BIB11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biopsych.2005.05.025","article-title":"Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase study","volume":"58","author":"Rush","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20540-BIB12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.biopsych.2008.05.034","article-title":"Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression","volume":"64","author":"Lozano","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20540-BIB13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1001\/archpsyc.65.8.870","article-title":"Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment features","volume":"65","author":"Rush","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20540-BIB14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0893-133X(01)00313-X","article-title":"Do age of onset and course of illness predict different treatment outcome among DSM IV depressive disorders with atypical features?","volume":"26","author":"Stewart","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/da.20540-BIB15","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/cercor\/bhm167","article-title":"Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression","volume":"18","author":"Johansen-Berg","year":"2008","journal-title":"Cereb Cortex"},{"key":"10.1002\/da.20540-BIB16","article-title":"Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts antidepressant response to ketamine","author":"Salvadore","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20540-BIB17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20540-BIB18","unstructured":"http:\/\/www.nia.nih.gov\/Alzheimers\/ResearchInformation\/ClinicalTrials\/ADNI.htm. Accessed October 12, 2008."},{"key":"10.1002\/da.20540-BIB19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1176\/appi.ajp.2007.07071066","article-title":"Medication effects in neuroimaging studies of bipolar disorder","volume":"165","author":"Phillips","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20540-BIB20","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1038\/npp.2008.6","article-title":"Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR*D study","volume":"33","author":"Perlis","year":"2008","journal-title":"Neuropsychopharmacology"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fda.20540","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/da.20540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:02:34Z","timestamp":1671541354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.20540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"URL":"https:\/\/doi.org\/10.1002\/da.20540","relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}