{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:27Z","timestamp":1786977687733,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2130,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Depress. Anxiety"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1002\/da.20597","type":"journal-article","created":{"date-parts":[[2009,8,18]],"date-time":"2009-08-18T10:15:39Z","timestamp":1250590539000},"page":"1012-1017","source":"Crossref","is-referenced-by-count":45,"title":["Early onset of obsessive-compulsive disorder and associated comorbidity"],"prefix":"10.1155","volume":"26","author":[{"given":"Deborah","family":"Janowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Joergen","family":"Grabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ruhrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ettelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Buhtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hochrein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Schulze-Rauschenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ferber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Pukrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald J.","family":"Freyberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Klosterk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Falkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.1002\/da.20597-BIB1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1192\/S0007125000297833","article-title":"Epidemiology of obsessive-compulsive disorder","author":"Bebbington","year":"1998","journal-title":"Br J Psychiatry Suppl"},{"key":"10.1002\/da.20597-BIB2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1001\/archpsyc.1988.01800360042006","article-title":"The epidemiology of obsessive-compulsive disorder in five US communities","volume":"45","author":"Karno","year":"1988","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20597-BIB3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.comppsych.2004.06.009","article-title":"Twelve-month prevalence of obsessive-compulsive disorder in Konya, Turkey","volume":"45","author":"Cillicilli","year":"2004","journal-title":"Compr Psychiatry"},{"key":"10.1002\/da.20597-BIB4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-244X-4-2","article-title":"Prevalence of obsessive-compulsive disorder in Iran","volume":"4","author":"Mohammadi","year":"2004","journal-title":"BMC Psychiatry"},{"key":"10.1002\/da.20597-BIB5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00004583-199804000-00020","article-title":"Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the pediatric literature","volume":"37","author":"Geller","year":"1998","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1002\/da.20597-BIB6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/archpsyc.1989.01810040041007","article-title":"Obsessive-compulsive disorder in children and adolescents. Clinical phenomenology of 70 consecutive cases","volume":"46","author":"Swedo","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20597-BIB7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1176\/ajp.155.2.264","article-title":"Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases","volume":"155","author":"Swedo","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20597-BIB8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1542\/peds.2004-2058","article-title":"Association between streptococcal infection and obsessive-compulsive disorder, Tourette's syndrome, and tic disorder","volume":"116","author":"Mell","year":"2005","journal-title":"Pediatrics"},{"key":"10.1002\/da.20597-BIB9","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm892","article-title":"Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea","volume":"9","author":"Kirvan","year":"2003","journal-title":"Nat Med"},{"key":"10.1002\/da.20597-BIB10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1192\/bjp.187.4.314","article-title":"Incidence of anti-brain antibodies in children with obsessive-compulsive disorder","volume":"187","author":"Dale","year":"2005","journal-title":"Br J Psychiatry"},{"key":"10.1002\/da.20597-BIB11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/08916930500484757","article-title":"Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea","volume":"39","author":"Kirvan","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1002\/da.20597-BIB12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1192\/bjp.158.2.260","article-title":"Gender-divergent aetiological factors in obsessive-compulsive disorder","volume":"158","author":"Noshirvani","year":"1991","journal-title":"Br J Psychiatry"},{"key":"10.1002\/da.20597-BIB13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S0033291706008816","article-title":"Obsessive-compulsive disorder, tics, and anxiety in 6-year-old twins","volume":"37","author":"Bolton","year":"2007","journal-title":"Psychol Med"},{"key":"10.1002\/da.20597-BIB14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1176\/ajp.152.1.76","article-title":"A family study of obsessive-compulsive disorder","volume":"152","author":"Pauls","year":"1995","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20597-BIB15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00004583-199005000-00012","article-title":"Psychiatric disorders in first degree relatives of children and adolescents with obsessive-compulsive disorder","volume":"29","author":"Lenane","year":"1990","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1002\/da.20597-BIB16","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1176\/ajp.149.9.1244","article-title":"Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive-compulsive children","volume":"149","author":"Leonard","year":"1992","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20597-BIB17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1001\/archpsyc.57.4.358","article-title":"A family study of obsessive-compulsive disorder","volume":"57","author":"Nestadt","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20597-BIB18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0165-1781(92)90075-E","article-title":"Psychiatric disorders in the families of patients with obsessive-compulsive disorder","volume":"42","author":"Bellodi","year":"1992","journal-title":"Psychiatry Res"},{"key":"10.1002\/da.20597-BIB19","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1176\/ajp.2006.163.11.1986","article-title":"Familiality of obsessive-compulsive disorder in nonclinical and clinical subjects","volume":"163","author":"Grabe","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20597-BIB20","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1469-7610.2004.00382.x","article-title":"Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?","volume":"46","author":"Chabane","year":"2005","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1002\/da.20597-BIB21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0033291704003253","article-title":"Admixture analysis of age at onset in obsessive-compulsive disorder","volume":"35","author":"Delorme","year":"2005","journal-title":"Psychol Med"},{"key":"10.1002\/da.20597-BIB22","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1176\/appi.ajp.158.11.1899","article-title":"Adults with early-onset obsessive-compulsive disorder","volume":"158","author":"Ros\u00e1rio-Campos","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20597-BIB23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0193-953X(05)70348-8","article-title":"Tic disorders","volume":"20","author":"Leckman","year":"1997","journal-title":"Psychiatr Clin North Am"},{"key":"10.1002\/da.20597-BIB24","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1097\/00004583-199511000-00008","article-title":"Obsessive-compulsive disorder in a birth cohort of 18-year-olds: prevalence and predictors","volume":"34","author":"Douglass","year":"1995","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1002\/da.20597-BIB25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0193-953X(05)70349-X","article-title":"Obsessive-compulsive disorder","volume":"20","author":"Miguel","year":"1997","journal-title":"Psychiatr Clin North Am"},{"key":"10.1002\/da.20597-BIB26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00004583-200103000-00015","article-title":"Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: an exploratory SPECT study","volume":"40","author":"Busatto","year":"2001","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1002\/da.20597-BIB27","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0278-5846(97)00163-2","article-title":"Corpus callosal morphology in treatment-naive pediatric obsessive-compulsive disorder","volume":"21","author":"Rosenberg","year":"1997","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1002\/da.20597-BIB28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jad.2006.04.019","article-title":"Clinical features associated to refractory obsessive-compulsive disorder","volume":"94","author":"Ferr\u00e3o","year":"2006","journal-title":"J Affect Disord"},{"key":"10.1002\/da.20597-BIB29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0022-3956(02)00087-0","article-title":"Early- and late-onset obsessive-compulsive disorder in adult patients: an exploratory clinical and therapeutic study","volume":"37","author":"Fontenelle","year":"2003","journal-title":"J Psychiatr Res"},{"key":"10.1002\/da.20597-BIB30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.eurpsy.2008.01.002","article-title":"Obsessive-compulsive disorder: influence of age at onset on comorbidity patterns","volume":"23","author":"de Mathis","year":"2008","journal-title":"Eur Psychiatry"},{"key":"10.1002\/da.20597-BIB31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/BF01324255","article-title":"Study of Health in Pomerania (SHIP): a health examination survey in an east German region: objectives and design","volume":"46","author":"John","year":"2001","journal-title":"Soz Praventivmed"},{"key":"10.1002\/da.20597-BIB32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000257972","article-title":"Die Yale-Brown Obsessive-Compulsive Scale (Y-BOCS): Ein halbstrukturiertes Interview zur Beurteilung des Schweregrades von Denk- undHandlungszw\u00e4ngen","volume":"1","author":"Hand","year":"1991","journal-title":"Verhaltenstherapie"},{"key":"10.1002\/da.20597-BIB33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0022-3956(86)90034-8","article-title":"Schedule for Affective Disorders and Schizophrenia-Lifetime Version modified for the study of anxiety disorders (SADS-LA): rationale and conceptual development","volume":"20","author":"Mannuzza","year":"1986","journal-title":"J Psychiatr Res"},{"key":"10.1002\/da.20597-BIB34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1192\/S0007125000297845","article-title":"Treatment of obsessive-compulsive spectrum disorders with SSRIs","author":"Hollander","year":"1998","journal-title":"Br J Psychiatry Suppl"},{"key":"10.1002\/da.20597-BIB35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0447.2006.00835.x","article-title":"Impulsiveness in obsessive-compulsive disorder: results from a family study","volume":"115","author":"Ettelt","year":"2007","journal-title":"Acta Psychiatr Scand"},{"key":"10.1002\/da.20597-BIB36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1176\/appi.ajp.157.2.281","article-title":"MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection","volume":"157","author":"Giedd","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20597-BIB37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pscychresns.2008.12.007","article-title":"Brain changes in children and adolescents with obsessive-compulsive disorder before and after treatment: a voxel-based morphometric MRI study","volume":"172","author":"Lazaro","year":"2009","journal-title":"Psychiatry Res"},{"key":"10.1002\/da.20597-BIB38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/1467-9280.24411","article-title":"Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging","volume":"14","author":"Ursu","year":"2003","journal-title":"Psychol Sci"},{"key":"10.1002\/da.20597-BIB39","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1017\/S0033291704004295","article-title":"Cognitive control in childhood-onset obsessive-compulsive disorder: a functional MRI study","volume":"35","author":"Viard","year":"2005","journal-title":"Psychol Med"},{"key":"10.1002\/da.20597-BIB40","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1176\/appi.ajp.161.6.1049","article-title":"Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder","volume":"161","author":"Szeszko","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20597-BIB41","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/archneur.1994.00540230083017","article-title":"Tourette's syndrome is part of a clinical spectrum that includes normal brain development","volume":"51","author":"Kurlan","year":"1994","journal-title":"Arch Neurol"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fda.20597","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/da.20597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T07:07:28Z","timestamp":1685084848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.20597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"URL":"https:\/\/doi.org\/10.1002\/da.20597","relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}