{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:58:02Z","timestamp":1788055082421,"version":"build-2784847793"},"reference-count":69,"publisher":"Hindawi Limited","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2130,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Depress. Anxiety"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1002\/da.20611","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T21:09:22Z","timestamp":1252703362000},"page":"1004-1011","source":"Crossref","is-referenced-by-count":87,"title":["Genetic and environmental influences on the co-morbidity between depression, panic disorder, agoraphobia, and social phobia: a twin study"],"prefix":"10.1155","volume":"26","author":[{"given":"Miriam A.","family":"Mosing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Medland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixie J.","family":"Statham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot C.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi R.","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"10.1002\/da.20611-BIB1","first-page":"82","volume-title":"The Burden of Disease and Injury in Australia 2003","author":"Begg","year":"2007"},{"key":"10.1002\/da.20611-BIB2","first-page":"47","article-title":"Epidemiology of major depressive disorder","volume":"27","author":"Landi","year":"2008","journal-title":"Quaderni Italiani di Psichiatria"},{"key":"10.1002\/da.20611-BIB3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S0033291707002012","article-title":"Co-morbid major depression and generalized anxiety disorders in the National Comborbity Survey follow-up","volume":"38","author":"Kessler","year":"2008","journal-title":"Psychol Med"},{"key":"10.1002\/da.20611-BIB4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/mpr.138","article-title":"The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) surveys (vol. 12, p 3, 2003)","volume":"12","author":"Andrade","year":"2003","journal-title":"Int J Methods Psychiatric Res"},{"key":"10.1002\/da.20611-BIB5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1034\/j.1600-0447.2002.1r103.x","article-title":"Social phobia: overview of community surveys","volume":"105","author":"Furmark","year":"2002","journal-title":"Acta Psychiatr Scand"},{"key":"10.1002\/da.20611-BIB6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1034\/j.1600-0447.108.s417.2.x","article-title":"The impairments caused by social phobia in the general population: implications for intervention","volume":"108","author":"Kessler","year":"2003","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1002\/da.20611-BIB7","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1002\/da.20611-BIB8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000116608","article-title":"Agoraphobia and panic","volume":"77","author":"Wittchen","year":"2008","journal-title":"Psychother Psychosom"},{"key":"10.1002\/da.20611-BIB9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-0327(02)00040-X","article-title":"Prevalence and correlates of DSM-IV major depression in an Australian National Survey","volume":"75","author":"Wilhelm","year":"2003","journal-title":"J Affect Disord"},{"key":"10.1002\/da.20611-BIB10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/00005053-200209000-00008","article-title":"Agoraphobia without a history of panic disorder may be part of the panic disorder syndrome","volume":"190","author":"Andrews","year":"2002","journal-title":"J Nervous Mental Dis"},{"key":"10.1002\/da.20611-BIB11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1017\/S0033291703007621","article-title":"Social phobia in the Australian National Survey of Mental Health and Well-Being (NSMHWB)","volume":"33","author":"Lampe","year":"2003","journal-title":"Psychol Med"},{"key":"10.1002\/da.20611-BIB12","volume-title":"Comorbidity of Mood and Anxiety Disorders","author":"Maser","year":"1990"},{"key":"10.1002\/da.20611-BIB13","first-page":"179","volume-title":"Textbook in Psychiatric Epidemiology","author":"Kessler","year":"1995"},{"key":"10.1002\/da.20611-BIB14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1192\/S0007125000293483","article-title":"Prevalence of anxiety disorders and their comorbidity with mood and addictive disorders","volume":"173","author":"Regier","year":"1998","journal-title":"Br J Psychiatry"},{"key":"10.1002\/da.20611-BIB15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1192\/S0007125000298371","article-title":"Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey","volume":"168","author":"Kessler","year":"1996","journal-title":"Br J Psychiatry"},{"key":"10.1002\/da.20611-BIB16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF02190407","article-title":"Comorbidity and social phobia-evidence from clinical, epidemiologic, and genetic-studies","volume":"244","author":"Merikangas","year":"1995","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1002\/da.20611-BIB17","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/BF02190406","article-title":"Classification and epidemiology of social phobia","volume":"244","author":"Lepine","year":"1995","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1002\/da.20611-BIB18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.janxdis.2003.10.001","article-title":"Agoraphobic behavior and panic attack: a study of male twins","volume":"18","author":"Tsuang","year":"2004","journal-title":"J Anxiety Disord"},{"key":"10.1002\/da.20611-BIB19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1017\/S003329170400412X","article-title":"The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies","volume":"35","author":"Middeldorp","year":"2005","journal-title":"Psychol Med"},{"key":"10.1002\/da.20611-BIB20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1017\/S0924933800001930","article-title":"Lifetime prevalence of depression and family history of patients with panic disorder and social phobia","volume":"8","author":"Bellodi","year":"1993","journal-title":"Eur Psychiatry"},{"key":"10.1002\/da.20611-BIB21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jad.2003.12.015","article-title":"Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder\/agoraphobia and major depression","volume":"82","author":"Biederman","year":"2004","journal-title":"J Affect Disord"},{"key":"10.1002\/da.20611-BIB22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1522-7154(1996)2:4<173::AID-ANXI3>3.0.CO;2-P","article-title":"Panic disorder and social phobia: effects of comorbidity on familial transmission","volume":"2","author":"Fyer","year":"1996","journal-title":"Anxiety"},{"key":"10.1002\/da.20611-BIB23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archpsyc.1995.03950190046007","article-title":"Specificity in familial aggregation of phobic disorders","volume":"52","author":"Fyer","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB24","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/da.20425","article-title":"Differential familial liability of panic disorder and agoraphobia","volume":"25","author":"Nocon","year":"2008","journal-title":"Depress Anxiety"},{"key":"10.1002\/da.20611-BIB25","first-page":"375","volume-title":"The familial relationship between panic disorder and unipolar depression","volume":"29","author":"Maier","year":"1995"},{"key":"10.1002\/da.20611-BIB26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archpsyc.1986.01800030037004","article-title":"Relationship between panic disorder and agoraphobia-a family study","volume":"43","author":"Noyes","year":"1986","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/da.20122","article-title":"Parental predictors of pediatric panic disorder\/agoraphobia: a controlled study in high-risk offspring","volume":"22","author":"Biederman","year":"2005","journal-title":"Depress Anxiety"},{"key":"10.1002\/da.20611-BIB28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1001\/archpsyc.1983.01790090027004","article-title":"A family study of panic disorder","volume":"40","author":"Crowe","year":"1983","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB29","first-page":"117","volume-title":"American Psychopathological Association Series: Anxiety: New Research and Changing Concepts","author":"Carey","year":"1981"},{"key":"10.1002\/da.20611-BIB30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00005053-200107000-00001","article-title":"A population-based twin study of generalized anxiety disorder in men and women","volume":"189","author":"Hettema","year":"2001","journal-title":"J Nerv Ment Dis"},{"key":"10.1002\/da.20611-BIB31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1017\/S003329170002849X","article-title":"Panic disorder in women-a population-based twin study","volume":"23","author":"Kendler","year":"1993","journal-title":"Psychol Med"},{"key":"10.1002\/da.20611-BIB32","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/archpsyc.60.9.929","article-title":"The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women","volume":"60","author":"Kendler","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB33","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1001\/archpsyc.1995.03950170048007","article-title":"The structure of the genetic and environmental risk-factors for 6 major psychiatric-disorders in women-phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism","volume":"52","author":"Kendler","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-0327(99)00031-2","article-title":"Evidence for genetic influences common and specific to symptoms of generalized anxiety and panic","volume":"57","author":"Scherrer","year":"2000","journal-title":"J Affect Disord"},{"key":"10.1002\/da.20611-BIB35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0165-1781(97)85177-3","article-title":"Panic attacks: a twin study","volume":"66","author":"Perna","year":"1997","journal-title":"Psychiatry Res"},{"key":"10.1002\/da.20611-BIB36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1375\/twin.8.6.609","article-title":"Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings","volume":"8","author":"Middeldorp","year":"2005","journal-title":"Twin Res Hum Genet"},{"key":"10.1002\/da.20611-BIB37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ajmg.c.30171","article-title":"What is the genetic relationship between anxiety and depression?","volume":"148C","author":"Hettema","year":"2008","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1002\/da.20611-BIB38","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic epidemiology of major depression: review and meta-analysis","volume":"157","author":"Sullivan","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20611-BIB39","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1017\/S0033291799002275","article-title":"Social phobia in a population-based female adolescent twin sample: co-morbidity and associated suicide-related symptoms","volume":"30","author":"Nelson","year":"2000","journal-title":"Psychol Med"},{"key":"10.1002\/da.20611-BIB40","first-page":"10","volume-title":"Heritability of social anxiety-a brief review","volume":"54","author":"Fyer","year":"1993"},{"key":"10.1002\/da.20611-BIB41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0447.1993.tb03419.x","article-title":"A twin study of DSM-III-R anxiety disorders","volume":"88","author":"Skre","year":"1993","journal-title":"Acta Psychiatr Scand"},{"key":"10.1002\/da.20611-BIB42","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/archpsyc.1983.01790090047007","article-title":"Genetic-factors in anxiety disorders","volume":"40","author":"Torgersen","year":"1983","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0022-3956(95)00024-Y","article-title":"The familial relationship between panic disorder and unipolar depresssion","volume":"29","author":"Maier","year":"1995","journal-title":"J Psychiatr Res"},{"key":"10.1002\/da.20611-BIB44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1176\/ajp.145.3.293","article-title":"Depression and panic attacks-the significance of overlap as reflected in follow-up and family study data","volume":"145","author":"Coryell","year":"1988","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20611-BIB45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00041444-199322000-00002","article-title":"Family study of panic disorder-comparison with generalized anxiety disorder, major depression and normal subjects","volume":"3","author":"Mendlewicz","year":"1993","journal-title":"Psychiatr Genet"},{"key":"10.1002\/da.20611-BIB46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/archpsyc.58.3.257","article-title":"The genetic epidemiology of irrational fears and phobias in men","volume":"58","author":"Kendler","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB47","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/archpsyc.1993.01820220017003","article-title":"The relationship between panic disorder and major depression-a new family study","volume":"50","author":"Weissman","year":"1993","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB48","volume-title":"Textbook in psychiatric epidemiology","author":"Horwath","year":"1995"},{"key":"10.1002\/da.20611-BIB49","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1017\/S0033291703007487","article-title":"Family study of co-morbidity between major depressive disorder and anxiety disorders","volume":"33","author":"Klein","year":"2003","journal-title":"Psychol Med"},{"key":"10.1002\/da.20611-BIB50","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/0145445506297015","article-title":"Anxiety sensitivity-a missing piece to the agoraphobia-without-panic puzzle","volume":"31","author":"Hayward","year":"2007","journal-title":"Behav Modif"},{"key":"10.1002\/da.20611-BIB51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1192\/bjp.bp.105.010827","article-title":"Agoraphobia in adults: incidence and longitudinal relationship with panic","volume":"188","author":"Bienvenu","year":"2006","journal-title":"Br J Psychiatry"},{"key":"10.1002\/da.20611-BIB52","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1046\/j.1360-0443.1999.94913618.x","article-title":"A validity study of the SSAGA-a comparison with the SCAN","volume":"94","author":"Hesselbrock","year":"1999","journal-title":"Addiction"},{"key":"10.1002\/da.20611-BIB53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15288\/jsa.1994.55.149","article-title":"A new, semistructured psychiatric interview for use in genetic-linkage studies-a report on the reliability of the Ssaga","volume":"55","author":"Bucholz","year":"1994","journal-title":"J Stud Alcohol"},{"key":"10.1002\/da.20611-BIB54","doi-asserted-by":"crossref","first-page":"500","DOI":"10.15288\/jsa.1995.56.500","article-title":"Reliability of individual diagnostic criterion items for psychoactive substance dependence and the impact on diagnosis","volume":"56","author":"Bucholz","year":"1995","journal-title":"J Stud Alcohol"},{"key":"10.1002\/da.20611-BIB55","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1017\/S0033291797005643","article-title":"Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men","volume":"27","author":"Heath","year":"1997","journal-title":"Psychol Med"},{"key":"10.1002\/da.20611-BIB56","volume-title":"Introduction to Quantitative Genetics","author":"Falconer","year":"1996"},{"key":"10.1002\/da.20611-BIB57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01067551","article-title":"A test of the equal-environment assumption in twin studies of psychiatric-illness","volume":"23","author":"Kendler","year":"1993","journal-title":"Behav Genet"},{"key":"10.1002\/da.20611-BIB58","volume-title":"Mx: Statistical Modelling. VCU Box 900126","author":"Neale","year":"2002"},{"key":"10.1002\/da.20611-BIB59","volume-title":"Methodology for Genetic Studies of Twins and Families","author":"Neale","year":"2004"},{"key":"10.1002\/da.20611-BIB60","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/BF01065638","article-title":"Bias in the estimation of heritability from truncated samples of twins","volume":"12","author":"Martin","year":"1982","journal-title":"Behav Genet"},{"key":"10.1002\/da.20611-BIB61","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF01082466","article-title":"Estimating and controlling for the effects of volunteer bias with pairs of relatives","volume":"23","author":"Neale","year":"1993","journal-title":"Behav Genet"},{"key":"10.1002\/da.20611-BIB62","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/archpsyc.56.6.557","article-title":"Major depressive disorder in a community-based twin sample-are there different genetic and environmental contributions for men and women?","volume":"56","author":"Bierut","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB63","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","article-title":"A review and meta-analysis of the genetic epidemiology of anxiety disorders","volume":"158","author":"Hettema","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20611-BIB64","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/archpsyc.1986.01800030023002","article-title":"Symptoms of anxiety and depression in a volunteer twin population. The etiologic role of genetic and environmental factors","volume":"43","author":"Kendler","year":"1986","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB65","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/gepi.1370010202","article-title":"Genetic covariation between neuroticism and the symptoms of anxiety and depression","volume":"1","author":"Jardine","year":"1984","journal-title":"Genet Epidemiol"},{"key":"10.1002\/da.20611-BIB66","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1001\/archpsyc.1987.01800170073010","article-title":"Symptoms of anxiety and symptoms of depression-same genes, different environments","volume":"44","author":"Kendler","year":"1987","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB67","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archpsyc.1992.01820040025003","article-title":"The genetic epidemiology of phobias in women-the interrelationship of agoraphobia, social phobia, situational phobia, and simple phobia","volume":"49","author":"Kendler","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB68","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archpsyc.55.11.1017","article-title":"The relationship of agoraphobia and panic in a community sample of adolescents and young adults","volume":"55","author":"Wittchen","year":"1998","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20611-BIB69","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10519-005-5355-9","article-title":"Cholesky problems","volume":"35","author":"Carey","year":"2005","journal-title":"Behav Genet"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fda.20611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/da.20611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:03:17Z","timestamp":1671541397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.20611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":69,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"URL":"https:\/\/doi.org\/10.1002\/da.20611","relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}