{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:25:24Z","timestamp":1792373124830,"version":"4.4.0"},"reference-count":60,"publisher":"Hindawi Limited","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2100,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Depress. Anxiety"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1002\/da.20629","type":"journal-article","created":{"date-parts":[[2009,11,15]],"date-time":"2009-11-15T00:29:17Z","timestamp":1258244957000},"page":"1110-1117","source":"Crossref","is-referenced-by-count":286,"title":["Single prolonged stress: toward an animal model of posttraumatic stress disorder"],"prefix":"10.1155","volume":"26","author":[{"given":"Shigeto","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Morinobu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fuchikami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Yamawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Liberzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"10.1002\/da.20629-BIB1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1002\/da.20629-BIB2","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/archpsyc.1995.03950240066012","article-title":"Posttraumatic stress disorder in the National Comorbidity Survey","volume":"52","author":"Kessler","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20629-BIB3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1037\/0021-843X.102.1.152","article-title":"Psychophysiological assessment of posttraumatic stress disorder imagery in World War II and Korean combat veterans","volume":"102","author":"Orr","year":"1993","journal-title":"J Abnorm Psychol"},{"key":"10.1002\/da.20629-BIB4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0306-4530(97)00044-9","article-title":"Stress-restress: effects on ACTH and fast feedback","volume":"22","author":"Liberzon","year":"1997","journal-title":"Psychoneuroendocrinology"},{"key":"10.1002\/da.20629-BIB5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-2826.1999.00288.x","article-title":"Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder","volume":"11","author":"Liberzon","year":"1999","journal-title":"J Neuroendocrinol"},{"key":"10.1002\/da.20629-BIB6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0006-8993(03)03033-6","article-title":"Endocrine, cognitive and hippocampal\/cortical 5HT 1A\/2A receptor changes evoked by a time-dependent sensitisation (TDS) stress model in rats","volume":"983","author":"Harvey","year":"2003","journal-title":"Brain Res"},{"key":"10.1002\/da.20629-BIB7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.physbeh.2006.12.008","article-title":"Stress vulnerabilities in an animal model of post-traumatic stress disorder","volume":"90","author":"Wakizono","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1002\/da.20629-BIB8","first-page":"155","article-title":"Present status and prospects about an animal model of post-traumatic stress disorder in rats using a shuttle box","volume":"26","author":"Shimizu","year":"2006","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"10.1002\/da.20629-BIB9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.physbeh.2006.08.032","article-title":"Hyperarousal does not depend on trauma-related contextual memory in an animal model of posttraumatic stress disorder","volume":"90","author":"Siegmund","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1002\/da.20629-BIB10","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jpsychires.2006.07.017","article-title":"A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear","volume":"41","author":"Siegmund","year":"2007","journal-title":"J Psychiatr Res"},{"key":"10.1002\/da.20629-BIB11","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.neubiorev.2005.04.010","article-title":"Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder","volume":"29","author":"Rau","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1002\/da.20629-BIB12","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1038\/sj.npp.1300523","article-title":"Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder","volume":"29","author":"Cohen","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/da.20629-BIB13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbr.2007.02.001","article-title":"Involvement of noradrenergic and corticoid receptors in the consolidation of the lasting anxiogenic effects of predator stress","volume":"179","author":"Adamec","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1002\/da.20629-BIB14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.neubiorev.2005.04.004","article-title":"Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response","volume":"30","author":"Adamec","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1002\/da.20629-BIB15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.euroneuro.2006.11.003","article-title":"Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover","volume":"17","author":"Cohen","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1002\/da.20629-BIB16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.biopsych.2006.03.013","article-title":"Anisomycin, a protein synthesis inhibitor, disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats","volume":"60","author":"Cohen","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20629-BIB17","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.neubiorev.2007.01.001","article-title":"PTSD and stress sensitisation: a tale of brain and body. Part 2: animal models","volume":"31","author":"Stam","year":"2007","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1002\/da.20629-BIB18","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.biopsych.2005.12.003","article-title":"Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats","volume":"59","author":"Cohen","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20629-BIB19","first-page":"283","article-title":"An animal model of posttraumatic stress disorder and its validity: effect of paroxetine on a PTSD model in rats","volume":"24","author":"Shimizu","year":"2004","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"10.1002\/da.20629-BIB20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1176\/ajp.150.1.83","article-title":"Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder","volume":"150","author":"Yehuda","year":"1993","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20629-BIB21","first-page":"41","article-title":"Biology of posttraumatic stress disorder","volume":"62","author":"Yehuda","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"10.1002\/da.20629-BIB22","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1176\/appi.ajp.161.8.1397","article-title":"The ACTH response to dexamethasone in PTSD","volume":"161","author":"Yehuda","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20629-BIB23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1001\/archpsyc.1995.03950190065010","article-title":"Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder","volume":"52","author":"Yehuda","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20629-BIB24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000125357","article-title":"Glucocorticoid feedback inhibition of adrenocorticotropic hormone secretagogue release. Relationship to corticosteroid receptor occupancy in various limbic sites","volume":"51","author":"Sapolsky","year":"1990","journal-title":"Neuroendocrinology"},{"key":"10.1002\/da.20629-BIB25","first-page":"274","article-title":"Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation","volume":"4","author":"Chambers","year":"1999","journal-title":"Semin Clin Neuropsychiatry"},{"key":"10.1002\/da.20629-BIB26","first-page":"494","article-title":"Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus","volume":"175","author":"Harvey","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/da.20629-BIB27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0924-977X(97)00050-3","article-title":"The role of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes","volume":"8","author":"Heresco-Levy","year":"1998","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1002\/da.20629-BIB28","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/sj.npp.1301605","article-title":"Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD","volume":"33","author":"Yamamoto","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/da.20629-BIB29","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0024-3205(98)00241-0","article-title":"GABA function in mood disorders: an update and critical review","volume":"63","author":"Shiah","year":"1998","journal-title":"Life Sci"},{"key":"10.1002\/da.20629-BIB30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/sj.mp.4002054","article-title":"Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder","volume":"13","author":"Geuze","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1002\/da.20629-BIB31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00213-003-1634-4","article-title":"Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD","volume":"172","author":"Khan","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/da.20629-BIB32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/archpsyc.60.3.283","article-title":"Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: association with posttraumatic stress disorder","volume":"60","author":"Orr","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20629-BIB33","first-page":"234","article-title":"Psychophysiological alterations in post-traumatic stress disorder","volume":"4","author":"Pitman","year":"1999","journal-title":"Semin Clin Neuropsychiatry"},{"key":"10.1002\/da.20629-BIB34","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.pnpbp.2006.12.010","article-title":"Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats","volume":"31","author":"Iwamoto","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1002\/da.20629-BIB35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2007.05.041","article-title":"Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model","volume":"148","author":"Kohda","year":"2007","journal-title":"Neuroscience"},{"key":"10.1002\/da.20629-BIB36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00213-006-0545-6","article-title":"Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats","volume":"189","author":"Takahashi","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/da.20629-BIB37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbr.2006.06.012","article-title":"Importance of early environment in the development of post-traumatic stress disorder-like behaviors","volume":"173","author":"Imanaka","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1002\/da.20629-BIB38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/da.20629-BIB39","first-page":"348","article-title":"Adaptation of the tail suspension test to the rat","volume":"17","author":"Chermat","year":"1986","journal-title":"J Pharmacol"},{"key":"10.1002\/da.20629-BIB40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.biopsych.2006.03.010","article-title":"Prefrontal mechanisms in extinction of conditioned fear","volume":"60","author":"Quirk","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20629-BIB41","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.biopsych.2006.06.004","article-title":"Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research\u00e2\u0080\u0094past, present, and future","volume":"60","author":"Rauch","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.20629-BIB42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsycho.2006.01.008","article-title":"Fear extinction in rats: implications for human brain imaging and anxiety disorders","volume":"73","author":"Milad","year":"2006","journal-title":"Biol Psychol"},{"key":"10.1002\/da.20629-BIB43","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1196\/annals.1301.012","article-title":"Applying learning principles to the treatment of post-trauma reactions","volume":"1008","author":"Rothbaum","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1002\/da.20629-BIB44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jpsychires.2008.01.017","article-title":"Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study","volume":"42","author":"Milad","year":"2008","journal-title":"J Psychiatr Res"},{"key":"10.1002\/da.20629-BIB45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1017\/S1461145702003061","article-title":"Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder","volume":"5","author":"Heresco-Levy","year":"2002","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1002\/da.20629-BIB46","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archpsyc.61.11.1136","article-title":"Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear","volume":"61","author":"Ressler","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20629-BIB47","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.brat.2007.06.006","article-title":"Enhancing exposure-based therapy from a translational research perspective","volume":"45","author":"Hofmann","year":"2007","journal-title":"Behav Res Ther"},{"key":"10.1002\/da.20629-BIB48","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1523\/JNEUROSCI.22-06-02343.2002","article-title":"Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats","volume":"22","author":"Walker","year":"2002","journal-title":"J Neurosci"},{"key":"10.1002\/da.20629-BIB49","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1037\/0735-7044.118.3.505","article-title":"D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement","volume":"118","author":"Ledgerwood","year":"2004","journal-title":"Behav Neurosci"},{"key":"10.1002\/da.20629-BIB50","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1176\/ajp.150.7.1015","article-title":"Deficits in short-term memory in posttraumatic stress disorder","volume":"150","author":"Bremner","year":"1993","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20629-BIB51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0165-1781(95)02800-5","article-title":"Deficits in short-term memory in adult survivors of childhood abuse","volume":"59","author":"Bremner","year":"1995","journal-title":"Psychiatry Res"},{"key":"10.1002\/da.20629-BIB52","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1176\/ajp.152.7.973","article-title":"MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder","volume":"152","author":"Bremner","year":"1995","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.20629-BIB53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-1781(98)00030-4","article-title":"Acute and long-term behavioral correlates of underwater trauma\u00e2\u0080\u0094potential relevance to stress and post-stress syndromes","volume":"79","author":"Richter-Levin","year":"1998","journal-title":"Psychiatry Res"},{"key":"10.1002\/da.20629-BIB54","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/archpsyc.1990.01810180041007","article-title":"Naloxone-reversible analgesic response to combat-related stimuli in posttraumatic stress disorder. A pilot study","volume":"47","author":"Pitman","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/da.20629-BIB55","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0278-5846(86)90051-5","article-title":"Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case","volume":"10","author":"Willner","year":"1986","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1002\/da.20629-BIB56","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0079-6123(07)67011-3","article-title":"The functional neuroanatomy of PTSD: a critical review","volume":"167","author":"Liberzon","year":"2008","journal-title":"Prog Brain Res"},{"key":"10.1002\/da.20629-BIB57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0022-3956(02)00058-4","article-title":"Psychopharmacological treatment in PTSD: a critical review","volume":"36","author":"Albucher","year":"2002","journal-title":"J Psychiatr Res"},{"key":"10.1002\/da.20629-BIB58","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1196\/annals.1314.035","article-title":"Serotonin and stress: protective or malevolent actions in the biobehavioral response to repeated trauma?","volume":"1032","author":"Harvey","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1002\/da.20629-BIB59","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neulet.2008.06.031","article-title":"A modified single-prolonged stress model for post-traumatic stress disorder","volume":"441","author":"Wang","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1002\/da.20629-BIB60","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0006-3223(93)90001-T","article-title":"Criteria for rationally evaluating animal models of posttraumatic stress disorder","volume":"33","author":"Yehuda","year":"1993","journal-title":"Biol Psychiatry"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fda.20629","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/da.20629\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:03:22Z","timestamp":1671541402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.20629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"URL":"https:\/\/doi.org\/10.1002\/da.20629","relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}