{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:16:14Z","timestamp":1791202574225,"version":"4.2.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":502,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["10-000-1002"],"award-info":[{"award-number":["10-000-1002"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Depress Anxiety"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1002\/da.22262","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:54:13Z","timestamp":1397850853000},"page":"737-745","source":"Crossref","is-referenced-by-count":143,"title":["STRESS EXPOSURE ACROSS THE LIFE SPAN CUMULATIVELY INCREASES DEPRESSION RISK AND IS MODERATED BY NEUROTICISM"],"prefix":"10.1155","volume":"31","author":[{"given":"Christiaan H.","family":"Vinkers","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Brain Center Rudolf Magnus; University Medical Center Utrecht; Utrecht The Netherlands"},{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Brain Center Rudolf Magnus; Utrecht University; Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Jo\u00ebls","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience, Brain Center Rudolf Magnus; University Medical Center; Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Milaneschi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, EMGO institute for Health and Care research and Neuroscience Campus Amsterdam; VU University Medical Center; Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 S.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Brain Center Rudolf Magnus; University Medical Center Utrecht; Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda W.J.H.","family":"Penninx","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, EMGO institute for Health and Care research and Neuroscience Campus Amsterdam; VU University Medical Center; Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco P.M.","family":"Boks","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Brain Center Rudolf Magnus; University Medical Center Utrecht; Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"issue":"12","key":"10.1002\/da.22262-BIB0001|da22262-cit-0001","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies","volume":"49","author":"Heim","year":"2001","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1002\/da.22262-BIB0002|da22262-cit-0002","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1176\/ajp.156.6.837","article-title":"Causal relationship between stressful life events and the onset of major depression","volume":"156","author":"Kendler","year":"1999","journal-title":"Am J Psychiatry"},{"issue":"2","key":"10.1002\/da.22262-BIB0003|da22262-cit-0003","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1176\/appi.ajp.2011.11020335","article-title":"Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis","volume":"169","author":"Nanni","year":"2012","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1002\/da.22262-BIB0004|da22262-cit-0004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0165-0327(99)00127-5","article-title":"Reconfirming the role of life events for the timing of depressive episodes. A two-year prospective follow-up study","volume":"59","author":"Mundt","year":"2000","journal-title":"J Affect Disord"},{"key":"10.1002\/da.22262-BIB0005|da22262-cit-0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.psych.48.1.191","article-title":"The effects of stressful life events on depression","volume":"48","author":"Kessler","year":"1997","journal-title":"Annu Rev Psychol"},{"issue":"2","key":"10.1002\/da.22262-BIB0006|da22262-cit-0006","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1440-1614.2002.01007.x","article-title":"Life events, stress and depression: a review of recent findings","volume":"36","author":"Tennant","year":"2002","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1002\/da.22262-BIB0007|da22262-cit-0007","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.clinpsy.1.102803.143938","article-title":"Stress and depression","volume":"1","author":"Hammen","year":"2005","journal-title":"Annu Rev Clin Psychol"},{"issue":"4","key":"10.1002\/da.22262-BIB0008|da22262-cit-0008","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/08964289.1990.9934604","article-title":"Social insecurity, anxiety, and stressful events as antecedents of depressive symptoms","volume":"16","author":"Cummins","year":"1990","journal-title":"Behav Med"},{"issue":"1","key":"10.1002\/da.22262-BIB0009|da22262-cit-0009","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopsych.2011.11.022","article-title":"Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions","volume":"72","author":"Ansell","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1002\/da.22262-BIB0010|da22262-cit-0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.1998.tb09546.x","article-title":"Stress, adaptation, and disease. Allostasis and allostatic load","volume":"840","author":"McEwen","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.1002\/da.22262-BIB0011|da22262-cit-0011","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.nbd.2012.03.012","article-title":"How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans","volume":"52","author":"Frodl","year":"2013","journal-title":"Neurobiol Dis"},{"key":"10.1002\/da.22262-BIB0012|da22262-cit-0012","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/npp.2013.250","article-title":"Cumulative adversity sensitizes neural response to acute stress: association with health Symptoms","volume":"39","author":"Seo","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/da.22262-BIB0013|da22262-cit-0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2013.06.008","article-title":"The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome","author":"Daskalakis","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"6103","key":"10.1002\/da.22262-BIB0014|da22262-cit-0014","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.1222942","article-title":"The science of resilience: implications for the prevention and treatment of depression","volume":"338","author":"Southwick","year":"2012","journal-title":"Science"},{"key":"10.1002\/da.22262-BIB0015|da22262-cit-0015","volume-title":"Manual of the Eysenck Personality Inventory","author":"Eysenck","year":"1975"},{"issue":"1","key":"10.1002\/da.22262-BIB0016|da22262-cit-0016","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1037\/0021-843X.103.1.103","article-title":"Temperament, personality, and the mood and anxiety disorders","volume":"103","author":"Clark","year":"1994","journal-title":"J Abnorm Psychol"},{"issue":"10","key":"10.1002\/da.22262-BIB0017|da22262-cit-0017","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1001\/archpsyc.63.10.1113","article-title":"Personality and major depression: a Swedish longitudinal, population-based twin study","volume":"63","author":"Kendler","year":"2006","journal-title":"Arch Gen Psychiatry"},{"issue":"11","key":"10.1002\/da.22262-BIB0018|da22262-cit-0018","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/archpsyc.1993.01820230023002","article-title":"A longitudinal twin study of personality and major depression in women","volume":"50","author":"Kendler","year":"1993","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"10.1002\/da.22262-BIB0019|da22262-cit-0019","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1037\/a0020327","article-title":"Linking \u201cbig\u201d personality traits to anxiety, depressive, and substance use disorders: a meta-analysis","volume":"136","author":"Kotov","year":"2010","journal-title":"Psychol Bull"},{"issue":"8","key":"10.1002\/da.22262-BIB0020|da22262-cit-0020","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1017\/S0033291707000244","article-title":"A longitudinal study of personality and major depression in a population-based sample of male twins","volume":"37","author":"Fanous","year":"2007","journal-title":"Psychol Med"},{"issue":"4","key":"10.1002\/da.22262-BIB0021|da22262-cit-0021","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1176\/appi.ajp.161.4.631","article-title":"The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression","volume":"161","author":"Kendler","year":"2004","journal-title":"Am J Psychiatry"},{"issue":"6","key":"10.1002\/da.22262-BIB0022|da22262-cit-0022","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1176\/appi.ajp.158.6.885","article-title":"The interplay and etiological continuity of neuroticism, difficulties, and life events in the etiology of major and subsyndromal, first and recurrent depressive episodes in later life","volume":"158","author":"Ormel","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1002\/da.22262-BIB0023|da22262-cit-0023","first-page":"1","article-title":"Cannabis use at a young age is associated with psychotic experiences","author":"Schubart","year":"2010","journal-title":"Psychol Med"},{"issue":"3","key":"10.1002\/da.22262-BIB0024|da22262-cit-0024","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/mpr.256","article-title":"The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods","volume":"17","author":"Penninx","year":"2008","journal-title":"Int J Methods Psychiatr Res"},{"key":"10.1002\/da.22262-BIB0025|da22262-cit-0025","volume-title":"Childhood Trauma Questionnaire: A Retrospective Self-Report. Manual","author":"Bernstein","year":"1998"},{"issue":"8","key":"10.1002\/da.22262-BIB0026|da22262-cit-0026","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.chiabu.2009.03.001","article-title":"A validation study of the Dutch Childhood Trauma Questionnaire-Short Form: factor structure, reliability, and known-groups validity","volume":"33","author":"Thombs","year":"2009","journal-title":"Child Abuse Negl"},{"issue":"4","key":"10.1002\/da.22262-BIB0027|da22262-cit-0027","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1176\/appi.ajp.159.4.620","article-title":"Risk factors for 12-month comorbidity of mood, anxiety, and substance use disorders: findings from the Netherlands Mental Health Survey and Incidence Study","volume":"159","author":"Graaf","year":"2002","journal-title":"Am J Psychiatry"},{"issue":"3","key":"10.1002\/da.22262-BIB0028|da22262-cit-0028","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1600-0447.2011.01828.x","article-title":"Impact of childhood life events and trauma on the course of depressive and anxiety disorders","volume":"126","author":"Hovens","year":"2012","journal-title":"Acta Psychiatr Scand"},{"key":"10.1002\/da.22262-BIB0029|da22262-cit-0029","first-page":"141","volume-title":"Instrumentation in Stress, Trauma, and Adaptation","author":"Wolfe","year":"1996"},{"issue":"1","key":"10.1002\/da.22262-BIB0030|da22262-cit-0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1017\/S003329170002105X","article-title":"The list of threatening experiences: a subset of 12 life event categories with considerable long-term contextual threat","volume":"15","author":"Brugha","year":"1985","journal-title":"Psychol Med"},{"key":"10.1002\/da.22262-BIB0031|da22262-cit-0031","article-title":"Alledaagse problemenlijst","author":"Vingerhoets","year":"1994","journal-title":"Lisse, Swets & Zeitlinger"},{"issue":"1","key":"10.1002\/da.22262-BIB0032|da22262-cit-0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00844845","article-title":"Comparison of two modes of stress measurement: daily hassles and uplifts versus major life events","volume":"4","author":"Kanner","year":"1981","journal-title":"J Behav Med"},{"issue":"6","key":"10.1002\/da.22262-BIB0033|da22262-cit-0033","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archgenpsychiatry.2009.50","article-title":"Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study","volume":"66","author":"Vreeburg","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"10.1002\/da.22262-BIB0034|da22262-cit-0034","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1017\/S0033291700035558","article-title":"The Inventory of Depressive Symptomatology (IDS): psychometric properties","volume":"26","author":"Rush","year":"1996","journal-title":"Psychol Med"},{"key":"10.1002\/da.22262-BIB0035|da22262-cit-0035","volume-title":"THC-concentraties in wiet, nederwiet en hasj in Nederlandse coffeeshops (2008-2009)","author":"Niesink","year":"2009"},{"issue":"1","key":"10.1002\/da.22262-BIB0036|da22262-cit-0036","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0447.2005.00741.x","article-title":"Validity and reliability of the CAPE: a self-report instrument for the measurement of psychotic experiences in the general population","volume":"114","author":"Konings","year":"2006","journal-title":"Acta Psychiatr Scand"},{"key":"10.1002\/da.22262-BIB0037|da22262-cit-0037","volume-title":"Revised NEO Personality Inventory (NEO-PI-R) and NEO Five Factor Inventory (NEO-FFI) Professional Manual","author":"Costa","year":"1992"},{"issue":"15","key":"10.1002\/da.22262-BIB0038|da22262-cit-0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v008.i15","article-title":"Effect displays in R for generalised linear models","volume":"8","author":"Fox","year":"2003","journal-title":"J Stat Softw"},{"key":"10.1002\/da.22262-BIB0039|da22262-cit-0039","first-page":"1","article-title":"Nlme: linear and nonlinearmixed effects models","volume":"3","author":"Pinheiro","year":"2012","journal-title":"R package version"},{"issue":"5","key":"10.1002\/da.22262-BIB0040|da22262-cit-0040","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/ije\/dym157","article-title":"Estimating interaction on an additive scale between continuous determinants in a logistic regression model","volume":"36","author":"Knol","year":"2007","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1002\/da.22262-BIB0041|da22262-cit-0041","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00001648-199209000-00012","article-title":"Confidence interval estimation of interaction","volume":"3","author":"Hosmer","year":"1992","journal-title":"Epidemiology"},{"issue":"3","key":"10.1002\/da.22262-BIB0042|da22262-cit-0042","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.psyneuen.2010.07.001","article-title":"Animal models for depression and the mismatch hypothesis of disease","volume":"36","author":"Schmidt","year":"2011","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"10.1002\/da.22262-BIB0043|da22262-cit-0043","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.physbeh.2011.12.008","article-title":"Mismatch or cumulative stress: toward an integrated hypothesis of programming effects","volume":"106","author":"Nederhof","year":"2012","journal-title":"Physiol Behav"},{"issue":"18","key":"10.1002\/da.22262-BIB0044|da22262-cit-0044","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/archinte.1993.00410180039004","article-title":"Stress and the individual. Mechanisms leading to disease","volume":"153","author":"McEwen","year":"1993","journal-title":"Arch Intern Med"},{"issue":"5","key":"10.1002\/da.22262-BIB0045|da22262-cit-0045","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.pnpbp.2004.05.031","article-title":"Can stress cause depression?","volume":"28","author":"Praag","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"5","key":"10.1002\/da.22262-BIB0046|da22262-cit-0046","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1017\/S0033291799008739","article-title":"Neuroticism and self-esteem as indices of the vulnerability to major depression in women","volume":"29","author":"Roberts","year":"1999","journal-title":"Psychol Med"},{"key":"10.1002\/da.22262-BIB0047|da22262-cit-0047","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-clinpsy-032210-104540","article-title":"Personality and depression: explanatory models and review of the evidence","volume":"7","author":"Klein","year":"2011","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1002\/da.22262-BIB0048|da22262-cit-0048","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.clinpsy.4.022007.141207","article-title":"Modern approaches to conceptualizing and measuring human life stress","volume":"4","author":"Monroe","year":"2008","journal-title":"Annu Rev Clin Psychol"},{"issue":"8","key":"10.1002\/da.22262-BIB0049|da22262-cit-0049","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"Bernstein","year":"1994","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1002\/da.22262-BIB0050|da22262-cit-0050","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1176\/appi.ajp.157.8.1243","article-title":"Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the \u201ckindling\u201d hypothesis","volume":"157","author":"Kendler","year":"2000","journal-title":"Am J Psychiatry"},{"issue":"4","key":"10.1002\/da.22262-BIB0051|da22262-cit-0051","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J Health Soc Behav"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fda.22262","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/da.22262\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:03:24Z","timestamp":1671541404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.22262"}},"subtitle":["Research Article: Cumulative Stress, Neuroticism, and Depression"],"short-title":[],"issued":{"date-parts":[[2014,4,17]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"URL":"https:\/\/doi.org\/10.1002\/da.22262","relation":{},"ISSN":["1091-4269"],"issn-type":[{"value":"1091-4269","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4,17]]}}}