{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:57:14Z","timestamp":1788267434226,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008240","name":"Fonds de Recherche du Qu\u00e9bec-Soci\u00e9t\u00e9 et Culture","doi-asserted-by":"publisher","award":["2020\u2010B2Z\u2010270683"],"award-info":[{"award-number":["2020\u2010B2Z\u2010270683"]}],"id":[{"id":"10.13039\/100008240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depress Anxiety"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1002\/da.22991","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T09:46:49Z","timestamp":1579254409000},"page":"512-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The genetic and environmental hierarchical structure of anxiety and depression in the UK Biobank"],"prefix":"10.1155","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5322-6252","authenticated-orcid":false,"given":"Genevieve","family":"Morneau\u2010Vaillancourt","sequence":"first","affiliation":[{"name":"Research Unit on Child Psychosocial Maladjustment, \u00c9cole de Psychologie, Facult\u00e9 des sciences socialesUniversit\u00e9 Laval Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-0944","authenticated-orcid":false,"given":"Jonathan R. I.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and NeuroscienceKing's College London London UK"},{"name":"National Institute of Health Research Biomedical Research CentreSouth London and Maudsley NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8110-5554","authenticated-orcid":false,"given":"Kirstin L.","family":"Purves","sequence":"additional","affiliation":[{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and NeuroscienceKing's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-0402","authenticated-orcid":false,"given":"Rosa","family":"Cheesman","sequence":"additional","affiliation":[{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and NeuroscienceKing's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-343X","authenticated-orcid":false,"given":"Christopher","family":"Rayner","sequence":"additional","affiliation":[{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and NeuroscienceKing's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2053-1792","authenticated-orcid":false,"given":"Gerome","family":"Breen","sequence":"additional","affiliation":[{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and NeuroscienceKing's College London London UK"},{"name":"National Institute of Health Research Biomedical Research CentreSouth London and Maudsley NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-0700","authenticated-orcid":false,"given":"Thalia C.","family":"Eley","sequence":"additional","affiliation":[{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and NeuroscienceKing's College London London UK"},{"name":"National Institute of Health Research Biomedical Research CentreSouth London and Maudsley NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8757"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-019-09951-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1262-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"e_1_2_9_8_1","article-title":"Genome\u2010wide genetic data on ~500 000 UK Biobank participants","author":"Bycroft C.","year":"2017","journal-title":"BioRxiv"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010814-015240"},{"key":"e_1_2_9_11_1","article-title":"Genome\u2010wide gene\u2010environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank","author":"Coleman J. R. I.","year":"2019","journal-title":"BioRxiv"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264312460275"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.24"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2018.12"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-008-9216-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-1849(99)80008-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.08.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.2.182"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691614568352"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0326-7"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0164027504268574"},{"key":"e_1_2_9_23_1","article-title":"Quality not quantity: Loneliness subtypes, psychological trauma, and mental health in the US adult population","volume":"3","author":"Hyland P.","year":"2018","journal-title":"Social Psychiatry and Psychiatric Epidemiology"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820090044008"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.9.929"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1121189X00001421"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.47"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.10.921"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713003012"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2011.11.028"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.1119"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.49.1.377"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.1.77"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.197"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0559-1"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/43.3-4.353"},{"key":"e_1_2_9_37_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2017"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700037533"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3971"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01161-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706008452"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219686110"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.10.1552"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2016.303431"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2013.03.010"},{"key":"e_1_2_9_47_1","first-page":"614","article-title":"Bias and confidence in not\u2010quite large samples","volume":"29","author":"Tukey J. W.","year":"1958","journal-title":"Annals of Mathematical Statistics"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.6.597"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.655"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.114.4.522"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0090-3"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/da.22991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/da.22991","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/da.22991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T08:07:34Z","timestamp":1671523654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.22991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,17]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/da.22991"],"URL":"https:\/\/doi.org\/10.1002\/da.22991","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.31234\/osf.io\/pzh9n","asserted-by":"object"}]},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,17]]},"assertion":[{"value":"2019-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}