{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:52:20Z","timestamp":1782298340356,"version":"3.54.5"},"reference-count":71,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012184","name":"Hersh Foundation","doi-asserted-by":"publisher","award":["CO\u2010MED trial (NCT00590863) was funded in part"],"award-info":[{"award-number":["CO\u2010MED trial (NCT00590863) was funded in part"]}],"id":[{"id":"10.13039\/100012184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["N01 MH\u201090003"],"award-info":[{"award-number":["N01 MH\u201090003"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25MH101078"],"award-info":[{"award-number":["R25MH101078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1002\/da.23006","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T21:44:52Z","timestamp":1584567892000},"page":"771-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Positive and negative valence systems in major depression have distinct clinical features, response to antidepressants, and relationships with immunomarkers"],"prefix":"10.1155","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-1192","authenticated-orcid":false,"given":"Gustavo C.","family":"Medeiros","sequence":"first","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2004-2382","authenticated-orcid":false,"given":"A. John","family":"Rush","sequence":"additional","affiliation":[{"name":"Academic Medicine Research Institute and Office Clinical SciencesDuke\u2010National University of Singapore Singapore"},{"name":"Department of PsychiatryDuke University Medical School Durham North Carolina"},{"name":"Department of PsychiatryTexas Tech Health Sciences Center Odessa Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-2391","authenticated-orcid":false,"given":"Manish","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"},{"name":"Department of PsychiatryIcahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Carmody","sequence":"additional","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-3774","authenticated-orcid":false,"given":"Jennifer L.","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0832-1760","authenticated-orcid":false,"given":"Andrew H.","family":"Czysz","sequence":"additional","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-3831","authenticated-orcid":false,"given":"Joseph M.","family":"Trombello","sequence":"additional","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-1370","authenticated-orcid":false,"given":"Crystal M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-1110","authenticated-orcid":false,"given":"Madhukar H.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of PsychiatryUniversity of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"567","article-title":"CD4+CD25(hi) regulatory T cells in healthy males and females mediate gender difference in the prevalence of autoimmune diseases","volume":"58","author":"Afshan G.","year":"2012","journal-title":"Clinica y Laboratorio"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14020181"},{"key":"e_1_2_8_4_1","volume-title":"Analyte Guide. Bio\u2010Plex Multiplex Immunoassays","author":"Bio\u2010Rad Laboratories","year":"2016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00108"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.037"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.35"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12671"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12669"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22490"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000396"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-126"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4438"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22202"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.09.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.033"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.06.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201934"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06111868"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.168"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.115"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2009.60.11.1439"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.06.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11071105"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7358(03)00070-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2218"},{"key":"e_1_2_8_29_1","unstructured":"IDS\u2010QIDS. (2018).Inventory Depressive Symptomatology (IDS) and Quick Inventory of Depressive Symptomatology (QIDS)."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09091379"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14188"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.05.017"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.01.023"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx060"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1998)7:1<3::AID-DA2>3.0.CO;2-F"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1747"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.105"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.17.2.214"},{"key":"e_1_2_8_39_1","first-page":"454","article-title":"Being bullied by same\u2010 versus other\u2010sex peers: Does it matter for adolescent victims?","volume":"42","author":"Little T. D.","year":"2013","journal-title":"Longitudinal Structural Equation Modeling"},{"key":"e_1_2_8_40_1","unstructured":"Mapi Research Trust. (2018).Inventory of Depressive Symptomatology (IDS\u2010SR and IDS\u2010C)."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.146"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"issue":"1","key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.31887\/DCNS.2012.14.1\/smorris","article-title":"Research domain criteria: Cognitive systems, neural circuits, and dimensions of behavior","volume":"14","author":"Morris S. E.","year":"2012","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.02.014"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.5.461"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.02.001"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.65"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.92"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050212-185606"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamapsychiatry.4"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9281-2"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700035558"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000821"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01866-8"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111645"},{"issue":"8","key":"e_1_2_8_56_1","first-page":"627","article-title":"STAR*D: Revising conventional wisdom","volume":"23","author":"Rush A. J.","year":"2009","journal-title":"CNS Drugs"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.03.005"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3381"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10993"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0073-7"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.2.jnp121"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1037\/1076-8998.10.4.344"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.08.058"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.03.001"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m06840"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67763-X"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.02.014"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711001905"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14010094"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2018.01.008"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2015.01.004"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.07.006"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fda.23006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/da.23006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/da.23006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/da.23006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:07:41Z","timestamp":1671541661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.23006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/da.23006"],"URL":"https:\/\/doi.org\/10.1002\/da.23006","archive":["Portico"],"relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"assertion":[{"value":"2019-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}