{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:16:31Z","timestamp":1789820191737,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1002\/da.23144","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T22:36:37Z","timestamp":1614119797000},"page":"431-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The contribution of early adverse stress to complex and severe depression in depressed outpatients"],"prefix":"10.1155","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-1306","authenticated-orcid":false,"given":"Sergio","family":"Gloger","sequence":"first","affiliation":[{"name":"Psicomedica, Clinical & Research Group Santiago Chile"},{"name":"Departamento de Psiquiatr\u00eda y Salud Mental Campus Oriente, Facultad de Medicina Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2460-4680","authenticated-orcid":false,"given":"Paul A.","family":"V\u00f6hringer","sequence":"additional","affiliation":[{"name":"Psicomedica, Clinical & Research Group Santiago Chile"},{"name":"Millennium Institute for Depression and Personality Research (MIDAP) Santiago Chile"},{"name":"Departamento de Psiquiatr\u00eda y Salud Mental Hospital Cl\u00ednico Universidad de Chile Santiago Chile"},{"name":"Mood Disorders Program Tufts Medical Center Boston Massachusetts USA"},{"name":"Department of Psychiatry Tufts University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4482-7993","authenticated-orcid":false,"given":"Pablo","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Psicomedica, Clinical & Research Group Santiago Chile"},{"name":"Millennium Institute for Depression and Personality Research (MIDAP) Santiago Chile"},{"name":"Departamento de Psiquiatr\u00eda y Salud Mental Hospital Cl\u00ednico Universidad de Chile Santiago Chile"},{"name":"N\u00facleo Milenio para Mejorar la Salud Mental de Adolescentes y J\u00f3venes (Imhay) Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7438-8031","authenticated-orcid":false,"given":"M. Victoria","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Psicomedica, Clinical & Research Group Santiago Chile"},{"name":"Millennium Institute for Depression and Personality Research (MIDAP) Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Psicomedica, Clinical & Research Group Santiago Chile"},{"name":"Millennium Institute for Depression and Personality Research (MIDAP) Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-1778","authenticated-orcid":false,"given":"Dante","family":"Diez de Medina","sequence":"additional","affiliation":[{"name":"Psicomedica, Clinical & Research Group Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-7190","authenticated-orcid":false,"given":"Marianne","family":"Cottin","sequence":"additional","affiliation":[{"name":"Millennium Institute for Depression and Personality Research (MIDAP) Santiago Chile"},{"name":"Escuela de Psicolog\u00eda Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"Facultad de Medicina Universidad de Chile Santiago Chile"},{"name":"Escuela de Psicolog\u00eda Universidad Finis Terrae Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-7866","authenticated-orcid":false,"given":"Alex","family":"Behn","sequence":"additional","affiliation":[{"name":"Millennium Institute for Depression and Personality Research (MIDAP) Santiago Chile"},{"name":"Escuela de Psicolog\u00eda Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7374"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.131792"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.03.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.00351.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2018.02.028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872020000300336"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30145-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.12.013"},{"key":"e_1_2_9_11_1","volume-title":"Trauma infanto\u2010juvenil y psicopatolog\u00eda adulta","author":"Cuneo C.","year":"2005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-7435(03)00123-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091936"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.420"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01477.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30286-X"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7424.1162"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095457941400090X"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(17)30118-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717002501"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S204265"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2222-4"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.06.045"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002743"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.451"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6844e1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2017.03.016"},{"key":"e_1_2_9_29_1","unstructured":"Ministerio de Salud de Chile. (2013). Gu\u00eda Cl\u00ednica Depresi\u00f3n en personas de 15 a\u00f1os y m\u00e1s.http:\/\/www.bibliotecaminsal.cl\/wp\/wp-content\/uploads\/2016\/04\/GUIA-CLINICA-DEPRESION-15-Y-MAS.pdf"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11020335"},{"key":"e_1_2_9_31_1","unstructured":"National Institute for Health and Care Excellence. (2009). Depression in adults: Recognition and management.https:\/\/www.nice.org.uk\/guidance\/cg90"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.180752"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1301300402"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.02.001"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.9.1202"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2018.02.013"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.21833"},{"issue":"3","key":"e_1_2_9_38_1","first-page":"324","article-title":"Protective factors in children's responses to stress and disadvantage","volume":"8","author":"Rutter M.","year":"1979","journal-title":"Annals of the Academy of Medicine, Singapore"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.22444"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.754"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2663"},{"key":"e_1_2_9_42_1","volume-title":"Stata Statistical Software (Release 14)","author":"StataCorp","year":"2015"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32521-z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2015.11.019"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.16m02051"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/15299732.2016.1212449"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901814010078"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.60.7.936"},{"key":"e_1_2_9_49_1","first-page":"1499","article-title":"Trauma infantojuvenil y psicopatolog\u00eda adulta: Un estudio emp\u00edrico","volume":"132","author":"Weil K. P.","year":"2004","journal-title":"Revista M\u00e9dica de Chile"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.1.49"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.61"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m07870"},{"key":"e_1_2_9_53_1","volume-title":"The ICD\u201010 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines","author":"World Health Organization","year":"1992"},{"key":"e_1_2_9_54_1","unstructured":"World Health Organization. (2017). Depression and other common mental disorders: Global health estimates (Press release).https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/254610\/WHO-MSD-MER-2017.2-eng.pdf"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/da.23144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/da.23144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/da.23144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:03:14Z","timestamp":1671541394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/da.23144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/da.23144"],"URL":"https:\/\/doi.org\/10.1002\/da.23144","archive":["Portico"],"relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"2020-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}