{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:00:17Z","timestamp":1780639217689,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1002\/dad2.12171","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T03:41:27Z","timestamp":1617162087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alzheimer's risk and quality of life: History of Down syndrome as a case in point"],"prefix":"10.1002","volume":"13","author":[{"given":"Wayne","family":"Silverman","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California, Irvine  Inglewood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Krinsky\u2010McHale","sequence":"additional","affiliation":[{"name":"Department of Psychology New York State Institute for Basic Research in Developmental Disabilities  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"e_1_2_3_2_1","unstructured":"Alzheimer's Association.Alzheimer's disease facts and figures (2020). Available from:https:\/\/www.alz.org\/media\/Documents\/alzheimers-facts-and-figures.pdf."},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"issue":"3","key":"e_1_2_3_4_1","first-page":"353","article-title":"Alzheimer's disease in Down syndrome","volume":"1","author":"Head E","year":"2012","journal-title":"Eur J Neurodegener Dis"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20163"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1352\/2008.46:215-228"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.5.722a"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160836"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430316"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1718"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.22.98.169"},{"key":"e_1_2_3_12_1","first-page":"259","article-title":"Observations on an ethnic classification of idiots","volume":"3","author":"Down JL","year":"1866","journal-title":"London Hospital Report"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.980080612"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.105.2.102"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12084"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.04.018"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70191-6"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804766-8.00011-X"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0068-2"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.1724"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.991"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbx147"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.12171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.12171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.12171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:06:15Z","timestamp":1780635975000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.12171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/dad2.12171"],"URL":"https:\/\/doi.org\/10.1002\/dad2.12171","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12171"}}