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A dysbiotic index (DI) was defined at the genus level as the abundance ratio of known periodontal bacteria\u00a0to healthy bacteria.\u00a0Analysis of variance\/analysis of covariance (ANOVA\/ANCOVA), linear discriminant effect\u2010size analyses\u00a0(LEfSe) were used to determine the bacterial genera and species differences between the CSF biomarker groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (A\u03b2)42 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02 and 0.01) but not with P\u2010tau.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We show a selective relationship between periodontal disease bacterial dysbiosis and CSF biomarkers of amyloidosis, but not for tau.\u00a0Further modeling is needed to establish the direct link between oral bacteria and\u00a0A\u03b2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.12172","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T11:41:04Z","timestamp":1618227664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Periodontal dysbiosis associates with reduced CSF A\u03b242 in cognitively normal elderly"],"prefix":"10.1002","volume":"13","author":[{"given":"Angela R.","family":"Kamer","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implant Dentistry College of Dentistry New York University  New York 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