{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:00:28Z","timestamp":1780639228650,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":140,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1I1A1A01059454"],"award-info":[{"award-number":["NRF\u20102019R1I1A1A01059454"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lewy body\u2013related pathology is commonly observed at autopsy in individuals with dementia, but in vivo biomarkers for \u03b1\u2010synucleinopathy are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline cerebrospinal fluid (CSF) biomarkers, polygenic risk score (PRS) for Parkinson's disease (PRS\u2010PD) and Alzheimer's disease (PRS\u2010AD), longitudinal cognitive scores, and magnetic resonance imaging were measured in 217 participants from the Alzheimer's Disease Neuroimaging Initiative. Linear mixed models were used to find the relationship of CSF biomarkers and the PRS with cognition and cortical atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher PRS\u2010PD and PRS\u2010AD were associated with lower CSF \u03b1\u2010synuclein and amyloid beta (A\u03b2), respectively. Lower CSF \u03b1\u2010synuclein and the interaction of CSF \u03b1\u2010synuclein and A\u03b2 were associated with lower cognitive scores and global cortical atrophy most prominently in the occipital cortex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Lower CSF \u03b1\u2010synuclein could be a biomarker for \u03b1\u2010synucleinopathy, and the simultaneous evaluation of CSF biomarkers for AD and CSF \u03b1\u2010synuclein could reveal the independent and interactive effects on cognition and cortical atrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.12177","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T01:42:11Z","timestamp":1621647731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Interaction of CSF \u03b1\u2010synuclein and amyloid beta 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