{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:55:24Z","timestamp":1790531724682,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":132,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz & Dem Diag Ass & Dis Mo"],"published-print":{"date-parts":[[2021,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [\n C9orf72<\/jats:italic>\n ], 163 progranulin [\n GRN<\/jats:italic>\n ], and 73 microtubule\u2010associated protein tau [\n MAPT<\/jats:italic>\n ]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel\u2010based morphometry to investigate the underlying neural substrates of the FCSRT.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All symptomatic mutation carrier groups and presymptomatic\n MAPT<\/jats:italic>\n mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic\n C9orf72<\/jats:italic>\n group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic\n GRN<\/jats:italic>\n mutation carriers. Performance on the FCSRT correlated with executive function, particularly in\n C9orf72<\/jats:italic>\n mutation carriers, but also with memory and naming tasks in the\n MAPT<\/jats:italic>\n group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in\n C9orf72<\/jats:italic>\n and\n GRN<\/jats:italic>\n , but mainly temporal areas in\n MAPT<\/jats:italic>\n mutation carriers.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n The FCSRT detects presymptomatic deficits in\n C9orf72<\/jats:italic>\n \u2010 and\n MAPT<\/jats:italic>\n \u2010associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dad2.12185","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T03:44:27Z","timestamp":1620877467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study"],"prefix":"10.1002","volume":"13","author":[{"given":"Jackie 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