{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:01:00Z","timestamp":1791594060783,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":185,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG019724"],"award-info":[{"award-number":["P01 AG019724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG062422"],"award-info":[{"award-number":["P30 AG062422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AG045333"],"award-info":[{"award-number":["K24 AG045333"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG063911"],"award-info":[{"award-number":["U19 AG063911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG045390"],"award-info":[{"award-number":["U01 AG045390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 NS092089"],"award-info":[{"award-number":["U54 NS092089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AG051218"],"award-info":[{"award-number":["U01AG051218"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50AG016570"],"award-info":[{"award-number":["P50AG016570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50AG005142"],"award-info":[{"award-number":["P50AG005142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08AG022228"],"award-info":[{"award-number":["K08AG022228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG066444"],"award-info":[{"award-number":["P30 AG066444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG03991"],"award-info":[{"award-number":["P01 AG03991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG026276"],"award-info":[{"award-number":["P01 AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG032438"],"award-info":[{"award-number":["U19 AG032438"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG010133"],"award-info":[{"award-number":["P30 AG010133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG019771"],"award-info":[{"award-number":["R01 AG019771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG010133"],"award-info":[{"award-number":["P30 AG010133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG019771"],"award-info":[{"award-number":["R01 AG019771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG057739"],"award-info":[{"award-number":["R01 AG057739"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 LM013463"],"award-info":[{"award-number":["R01 LM013463"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG068193"],"award-info":[{"award-number":["R01 AG068193"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG068057"],"award-info":[{"award-number":["U01 AG068057"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD\u2010MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD\u2010MC and could help predict risk for dementia during trial enrollment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We created a dementia risk score by entering standardized gray\u2010matter volumes from 231 DIAD\u2010MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD\u2010MC followed longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our risk score separated asymptomatic versus demented DIAD\u2010MC with 96.4% (standard error\u00a0=\u00a00.02) and predicted conversion to dementia at next visit (hazard ratio\u00a0=\u00a01.32, 95% confidence interval [CI: 1.15, 1.49]) and within 2 years (area under the curve\u00a0=\u00a090.3%, 95% CI [82.3%\u201398.2%]) and improved prediction beyond established methods based on familial age of onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Individualized risk scores based on brain atrophy could be useful for establishing enrollment criteria and stratifying DIAD\u2010MC participants for prevention trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.12197","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T07:21:39Z","timestamp":1625469699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Ophir","family":"Keret","sequence":"first","affiliation":[{"name":"Global Brain Health Institute University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Staffaroni","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Ringman","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Cobigo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Yang M.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Elaine","family":"Allen","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute University of California  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Salloway","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeer","family":"Chhatwal","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School Boston  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly","family":"Reyes\u2010Dumeyer","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal J.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Neuropathology, Department of Pathology &amp; Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biostatistics, Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L.S.","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Neuropathology, Department of Pathology &amp; Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biostatistics, Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau M.","family":"Ances","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Neuropathology, Department of Pathology &amp; Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biostatistics, Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Joseph\u2010Mathurin","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Neuropathology, Department of Pathology &amp; Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biostatistics, Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Perrin","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Neuropathology, Department of Pathology &amp; Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biostatistics, Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Neuropathology, Department of Pathology &amp; Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biostatistics, Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Munich Germany"},{"name":"Department of Neurology Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"V\u00f6glein","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Munich Germany"},{"name":"Department of Neurology Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Jucker","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"la Foug\u00e8re","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Institute for Nuclear Medicine and Clinical Molecular Imaging Eberhard Karls University  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Macquarie University  North Ryde New South Wales Australia"},{"name":"Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Psychiatry and Clinical Neurosciences University of Western Australia  Crawley Western Australia Australia"},{"name":"Australian Alzheimer's Research Foundation  Nedlands Western Australia Australia"},{"name":"The Cooperative Research Centre for Mental Health  Carlton South Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Macquarie University  North Ryde New South Wales Australia"},{"name":"Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Psychiatry and Clinical Neurosciences University of Western Australia  Crawley Western Australia Australia"},{"name":"Australian Alzheimer's Research Foundation  Nedlands Western Australia Australia"},{"name":"The Cooperative Research Centre for Mental Health  Carlton South Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Australian Alzheimer's Research Foundation  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Therapy Austin Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Schofield","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Randwick  Sydney New South Wales Australia"},{"name":"School of Medical Sciences UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Randwick  Sydney New South Wales Australia"},{"name":"Prince of Wales Hospital Clinical School UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fulham","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging, Royal Prince Alfred Hospital, Sydney Medical School University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"The Florey Institute University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Radiology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill R.","family":"Graff\u2010Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center Center for Imaging of Neurodegenerative Diseases  San Francisco California USA"},{"name":"Department of Radiology University of California, San Francisco  San Francisco California USA"},{"name":"Department of Medicine University of California, San Francisco  San Francisco California USA"},{"name":"Department of Psychiatry University of California, San Francisco  San Francisco California USA"},{"name":"Department of Neurology University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Cash","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology University College London  London UK"},{"name":"Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo F.","family":"Allegri","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology, Neuropsychiatry and Neuropsychology Instituto de InvestigacionesNeurol\u00f3gicas FLENI  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Chrem","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology, Neuropsychiatry and Neuropsychology Instituto de InvestigacionesNeurol\u00f3gicas FLENI  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Yi","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute University of California  San Francisco California USA"},{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil D.","family":"Rabinovici","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute University of California  San Francisco California USA"},{"name":"Department of Neurology, Memory and Aging Center University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dominantly Inherited Alzheimer Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705971"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706441"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002609"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007941"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.04.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006277"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000596"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(09)70299\u20106"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a841c6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.06.2268"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.10.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102011\u2010302087"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30028\u20100"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317918110"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102010\u2010100678"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102012\u2010303299"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.17126"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz019"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511080924"},{"issue":"1","key":"e_1_2_7_23_1","first-page":"55","article-title":"Biomarker\u2010based prediction of progression in MCI: comparison of AD signature and hippocampal volume with spinal fluid amyloid\u2010beta and tau","volume":"5","author":"Dickerson BC","year":"2013","journal-title":"Front Aging Neurosci"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.04.007"},{"key":"e_1_2_7_25_1","unstructured":"National Institute on Aging \u2010 Alzheimer's Disease Research Centers n.d."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21049"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.039"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.014"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00197LK"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.786"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","unstructured":"LiuJ ChenJ YeJ.Large\u2010scale sparse logistic regression. Proc. ACM SIGKDD Int. Conf. Knowl. Discov. Data Min.2009.https:\/\/doi.org\/10.1145\/1557019.1557082","DOI":"10.1145\/1557019.1557082"},{"key":"e_1_2_7_34_1","article-title":"Scikit\u2010learn: machine learning in Python","volume":"12","author":"Pedregosa F","year":"2011","journal-title":"J Mach Learn Res"},{"key":"e_1_2_7_35_1","article-title":"SAGA: a fast incremental gradient method with support for non\u2010strongly convex composite objectives","author":"Defazio A","year":"2014","journal-title":"Adv Neural Inf Process Syst"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11222\u2010009\u20109153\u20108"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnp.12053"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.023"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq277"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.081"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101975"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70228\u20104"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.013"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30137\u2010X"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180078"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.12197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.12197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.12197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:08:24Z","timestamp":1780636104000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.12197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/dad2.12197"],"URL":"https:\/\/doi.org\/10.1002\/dad2.12197","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12197"}}