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Changes associated with PCA in the brain affect the visual cortex, but little is known about retinal changes in PCA. In this study, we explored retinal phenotypic variations in typical AD (tAD) and PCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retinal phenotyping was carried out on ultra\u2010widefield (UWF) images of 69 control, 24 tAD, and 25 PCA participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individuals with tAD (odds ratio [OR]\u00a0=\u00a02.76 [confidence interval (CI):1.24 to 6.10],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.012) and PCA (OR\u00a0=\u00a03.40 [CI:1.25 to 9.22],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.016) were more likely phenotyped as hard drusen. tAD (OR\u00a0=\u00a00.34 [CI:0.12 to 0.92],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.035) were less likely to have soft drusen compared to control. Almost 3\u2010fold increase in reticular pseudodrusen formation in tAD (OR\u00a0=\u00a02.93 [CI:1.10 to 7.76],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.030) compared to control was estimated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Studying the peripheral retina may contribute to a better understanding of differences in retinal phenotypes of different AD variants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.12232","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T06:58:26Z","timestamp":1629442706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retinal phenotyping of variants of Alzheimer's disease using ultra\u2010widefield retinal images"],"prefix":"10.1002","volume":"13","author":[{"given":"Lajos","family":"Csincsik","sequence":"first","affiliation":[{"name":"Wellcome\u2010Wolfson Institute for Experimental Medicine Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Quinn","sequence":"additional","affiliation":[{"name":"Centre for Public Health Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keir X. X.","family":"Yong","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian J.","family":"Crutch","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunde","family":"Peto","sequence":"additional","affiliation":[{"name":"Centre for Public Health Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Lengyel","sequence":"additional","affiliation":[{"name":"Wellcome\u2010Wolfson Institute for Experimental Medicine Queen's University Belfast  Belfast 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