{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:46:39Z","timestamp":1793025999277,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":90,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG031110"],"award-info":[{"award-number":["R01AG031110"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG051406"],"award-info":[{"award-number":["U01AG051406"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19 AG070043"],"award-info":[{"award-number":["U19 AG070043"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Drawing on the amyloid\/tau\/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [<jats:sup>18<\/jats:sup>F]AV\u20101451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (A\u03b2) PET in Down syndrome (DS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 123 non\u2010demented adults with DS (<jats:italic>M\u00a0<\/jats:italic>\u00a0=\u00a047 years, standard deviation\u00a0=\u00a06.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [T<jats:sub>H<\/jats:sub>] vs. low tau [T<jats:sub>L<\/jats:sub>]) variable. Global PET A\u03b2 SUVR was assessed as binary variable (A\u03b2\u2013 vs. A\u03b2+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the A\u03b2+ but not A\u03b2\u2013 group. The A\u03b2+\/T<jats:sub>H<\/jats:sub> group evidenced significantly worse episodic memory than the A\u03b2+\/T<jats:sub>L<\/jats:sub> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Similar to late\u2010onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12256","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:55:02Z","timestamp":1648860902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Role of tau deposition in early cognitive decline in Down syndrome"],"prefix":"10.1002","volume":"14","author":[{"given":"Sigan L.","family":"Hartley","sequence":"first","affiliation":[{"name":"Waisman Center University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"School of Human Ecology University of Wisconsin\u2010Madison  Madison 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