{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:06Z","timestamp":1772118246095,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Blood metabolomics\u2010based biomarkers may be useful to predict measures of neurocognitive aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We tested the association between 707 blood metabolites measured in 1451 participants from the Hispanic Community Health Study\/Study of Latinos (HCHS\/SOL), with mild cognitive impairment (MCI) and global cognitive change assessed 7 years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual\u2010metabolite analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 20 metabolites predicting prevalent MCI and\/or global cognitive change. Six of them were novel and 14 were previously reported as associated with neurocognitive aging outcomes. The MCI MRS comprised 61 metabolites and improved prediction accuracy from 84% (minimally adjusted model) to 89% in the entire dataset and from 75% to 87% among apolipoprotein E \u03b54 carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Blood metabolites may serve as biomarkers identifying individuals at risk for MCI among US Hispanics\/Latinos.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.12259","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T13:55:25Z","timestamp":1645624525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Blood metabolites predicting mild cognitive impairment in the study of Latinos\u2010investigation of neurocognitive aging (HCHS\/SOL)"],"prefix":"10.1002","volume":"14","author":[{"given":"Shan","family":"He","sequence":"first","affiliation":[{"name":"Department of Biostatistics Harvard T.H Chan School of Public Health  Boston Massachusetts USA"},{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einat","family":"Granot\u2010Hershkovitz","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Bressler","sequence":"additional","affiliation":[{"name":"Human Genetics Center School of Public Health, University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Tarraf","sequence":"additional","affiliation":[{"name":"Institute of Gerontology Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Yu","sequence":"additional","affiliation":[{"name":"Human Genetics Center School of Public Health, University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Gillings School of Global Public Health University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Wassertheil\u2010Smoller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; 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Population Health Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Division of Public Health Sciences Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Boerwinkle","sequence":"additional","affiliation":[{"name":"Human Genetics Center School of Public Health, University of Texas Health Science Center at Houston  Houston Texas USA"},{"name":"Human Genome Sequencing Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[{"name":"Brown Foundation Institute of Molecular Medicine McGovern Medical School The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer\u02bcs Disease Center University of California, Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Kristal","sequence":"additional","affiliation":[{"name":"Burke Medical Research Institute, White Plains  New York USA"},{"name":"Departments of Biochemistry and Neuroscience Weill Medical College of Cornell University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Shiley\u2010Marcos Alzheimer's Disease Center University of California, San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H Chan School of Public Health  Boston Massachusetts USA"},{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12068"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"1","article-title":"APOE alleles \u2019 association with cognitive function differs across Hispanic \/Latino groups and genetic ancestry in the study of Latinos\u2010investigation of neurocognitive aging ( HCHS \/ SOL )","volume":"17","author":"Granot\u2010Hershkovitz E","year":"2020","journal-title":"Alzheimer's Dement"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029857"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21326"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118656082.ch6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nhtm.2017.06.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00343"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.04.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063644"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.118"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.09.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.08.192"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.05.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.03.015"},{"key":"e_1_2_7_18_1","volume-title":"Six\u2010Item Screener to Identify Cognitive Impairment among Potential Subjects for Clinical Perkins and Hugh C. 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